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Institutional Investment Manager
ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC (CIK: 0001055951) incorporated in Delaware, located at 601 Lexington Avenue, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q3)
Portfolio Summary: 140 holdings with a total value of $8,780,843,000.
#
Name
Shares
Value ($)
%
Options
Notes
101 INOTEK PHARMACEUTICALS CORP 7,000,000 9,547,000 0.11% PRN
102 AFFIMED N V 3,375,000 9,383,000 0.11%
103 Nabriva Therapeutics AG 1,315,000 9,271,000 0.11%
104 AEGLEA BIOTHERAPEUTICS INC COM 1,360,224 8,719,000 0.10%
105 CELLECTIS S A 350,000 8,428,000 0.10%
106 PORTOLA PHARMACEUTICALS INC 370,900 8,423,000 0.10%
107 INCYTE CORP 4,250,000 8,267,000 0.09% PRN
108 SIENTRA INC 917,500 8,248,000 0.09%
109 NUVASIVE INC COM 123,500 8,233,000 0.09%
110 XENON PHARMACEUTICALS INC 1,000,000 8,100,000 0.09%
111 INCYTE CORP 4,250,000 8,090,000 0.09% PRN
112 MINERVA NEUROSCIENCES INC COM 556,200 7,851,000 0.09%
113 Redhill Biopharma Ltd 564,900 7,846,000 0.09%
114 FLUIDIGM CORP DEL 10,000,000 6,213,000 0.07% PRN
115 BRISTOL MYERS SQUIBB CO 100,000 5,392,000 0.06% Call
116 ADAPTIMMUNE THERAPEUTICS PLC 724,184 5,105,000 0.06%
117 INFINITY PHARMACEUTICALS INC COM 3,250,300 5,070,000 0.06%
118 GW PHARMACEUTICALS PLC 36,200 4,805,000 0.05%
119 VALEANT PHARMACEUTICALS INTL 194,900 4,785,000 0.05%
120 INVITAE CORP 456,666 4,000,000 0.05%
121 SANGAMO BIOSCIENCES INCORPORATED 831,500 3,850,000 0.04%
122 UNIQURE NV 489,000 3,741,000 0.04%
123 PERNIX THERAPEUTICS HOLDINGS INC 12,000,000 3,514,000 0.04% PRN
124 AMEDISYS INC COM 71,500 3,392,000 0.04%
125 ROKA BIOSCIENCE INC 3,220,429 2,238,000 0.03%
126 Cogentix Medical Inc 878,145 1,598,000 0.02%
127 OREXIGEN THERAPEUTICS INC 5,210,000 1,441,000 0.02% PRN
128 INTRA CELLULAR THERAPIES INC COM 90,000 1,373,000 0.02% Call
129 BIOLINERX LTD 1,038,600 1,194,000 0.01%
130 AMARIN CORP PLC 350,000 1,117,000 0.01%
131 MARINUS PHARMACEUTICALS INC 567,600 1,033,000 0.01%
132 QLT INC 500,000 1,030,000 0.01%
133 MEDIGUS LTD 600,000 756,000 0.01%
134 PERNIX THERAPEUTICS HLDGS IN 1,073,000 668,000 0.01%
135 BioMarin Pharmaceutical Inc 500,000 624,000 0.01% PRN
136 BIOMARIN PHARMACEUTICAL INC 500,000 600,000 0.01% PRN
137 XTANT MED HLDGS INC 475,439 537,000 0.01%
138 Nivalis Therapeutics Inc 59,000 480,000 0.01%
139 ALIMERA SCIENCES INC 250,000 373,000 0.00%
140 ARALEZ PHARMACEUTICALS INC 68,143 330,000 0.00%
Page 3 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001172661-16-004318, filed 2016.11.14).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.