| # | % | |||||
|---|---|---|---|---|---|---|
| 51 | BARCLAYS BK PLC IPATH S&P MT ETN | 3,972 | 5,485,000 | 0.29% | Call | |
| 52 | ALNYLAM PHARMACEUTICALS INC | 987 | 5,477,000 | 0.29% | Call | |
| 53 | SHIRE PLC | 29,550 | 5,440,000 | 0.28% | ||
| 54 | INTRA-CELLULAR THERAPIES INC | 1,373 | 5,330,000 | 0.28% | Call | |
| 55 | VERTEX PHARMACEUTICALS INC | 609 | 5,239,000 | 0.27% | Call | |
| 56 | EXPRESS INC | 665 | 5,041,000 | 0.26% | Put | |
| 57 | TEVA PHARMACEUTICAL INDS LTD | 1,000 | 5,023,000 | 0.26% | Put | |
| 58 | AMICUS THERAPEUTICS INC | 7,992 | 4,364,000 | 0.23% | Call | |
| 59 | PARATEK PHARMACEUTICALS INC | 305,964 | 4,256,000 | 0.22% | ||
| 60 | KITE PHARMA INC | 851 | 4,255,000 | 0.22% | Call | |
| 61 | DYNAVAX TECHNOLOGIES CORP | 290,505 | 4,236,000 | 0.22% | ||
| 62 | GLOBAL BLOOD THERAPEUTICS INCORPORATED | 254,029 | 4,214,000 | 0.22% | ||
| 63 | TOKAI PHARMACEUTICALS INC COM | 749,205 | 4,128,000 | 0.22% | ||
| 64 | CYTORI THERAPEUTICS INC | 1,966,708 | 4,110,000 | 0.21% | ||
| 65 | ARBUTUS BIOPHARMA CORP | 1,176,031 | 4,093,000 | 0.21% | ||
| 66 | CEMPRA INC | 2,340 | 3,859,000 | 0.20% | Put | |
| 67 | CEL SCI CORP | 8,163,816 | 3,755,000 | 0.20% | ||
| 68 | NEUROCRINE BIOSCIENCES INC | 813 | 3,695,000 | 0.19% | Call | |
| 69 | HORIZON PHARMA PLC | 2,205 | 3,632,000 | 0.19% | Call | |
| 70 | EIGER BIOPHARMACEUTICALS INC | 175,249 | 3,473,000 | 0.18% | ||
| 71 | NEWLINK GENETICS CORP | 5,771 | 3,463,000 | 0.18% | Call | |
| 72 | ALNYLAM PHARMACEUTICALS INC | 606 | 3,363,000 | 0.18% | Put | |
| 73 | INVIVO THERAPEUTICS HLDGS CORPORATION COM NEW | 580,343 | 3,354,000 | 0.17% | ||
| 74 | INTEC PHARMA LTD JERUSALEM | 743,545 | 3,346,000 | 0.17% | ||
| 75 | REGULUS THERAPEUTICS INC | 11,560 | 3,341,000 | 0.17% | Call | |
| 76 | LA JOLLA PHARMACEUTICAL CO | 206,131 | 3,298,000 | 0.17% | ||
| 77 | REGENXBIO INC COM | 411,926 | 3,295,000 | 0.17% | ||
| 78 | DURECT CORP | 2,540,278 | 3,099,000 | 0.16% | ||
| 79 | ACHILLION PHARMACEUTICALS INC | 3,827 | 2,985,000 | 0.16% | Call | |
| 80 | LION BIOTECHNOLOGIES INC COM | 367,242 | 2,975,000 | 0.16% | ||
| 81 | INTREXON CORPORATION | 120,359 | 2,962,000 | 0.15% | ||
| 82 | Nivalis Therapeutics Inc | 641,492 | 2,951,000 | 0.15% | ||
| 83 | ILLUMINA INC | 20,000 | 2,808,000 | 0.15% | ||
| 84 | BARCLAYS BK PLC IPATH S&P MT ETN | 260,000 | 2,805,000 | 0.15% | ||
| 85 | EDAP TMS S A SPONSORED ADR | 847,225 | 2,804,000 | 0.15% | ||
| 86 | INTREXON CORP | 1,136 | 2,796,000 | 0.15% | Put | |
| 87 | INTRA-CELLULAR THERAPIES INC | 71,943 | 2,793,000 | 0.15% | ||
| 88 | Pieris Pharmaceuticals | 1,615,992 | 2,602,000 | 0.14% | ||
| 89 | SANGAMO THERAPEUTICS INC | 4,400 | 2,548,000 | 0.13% | Call | |
| 90 | CEMPRA INC | 1,537 | 2,535,000 | 0.13% | Call | |
| 91 | OPKO HEALTH INC | 2,645 | 2,470,000 | 0.13% | Put | |
| 92 | OpGen Inc | 1,625,000 | 2,470,000 | 0.13% | ||
| 93 | ADVERUM BIOTECHNOLOGIES INC | 779,926 | 2,465,000 | 0.13% | ||
| 94 | Axovant Sciences LTD | 190,000 | 2,440,000 | 0.13% | ||
| 95 | VistaGen Therapeutics Inc | 623,317 | 2,431,000 | 0.13% | ||
| 96 | BIOGEN INC | 100 | 2,418,000 | 0.13% | Put | |
| 97 | BIOGEN INC | 10,000 | 2,418,000 | 0.13% | ||
| 98 | LA JOLLA PHARMACEUTICAL CO | 1,458 | 2,333,000 | 0.12% | Call | |
| 99 | ZOGENIX INC | 289,200 | 2,328,000 | 0.12% | ||
| 100 | IONIS PHARMACEUTICALS INC | 984 | 2,292,000 | 0.12% | Put |
Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-16-119067, filed 2016.08.15).
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
