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Institutional Investment Manager
ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC (CIK: 0001055951) incorporated in Delaware, located at 601 Lexington Avenue, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2014Q2)
Portfolio Summary: 132 holdings with a total value of $8,516,434,000.
#
Name
Shares
Value ($)
%
Options
Notes
51 CELLDEX THERAPEUTICS INC NEW 2,181,600 35,604,000 0.42%
52 BACTERIN INTL 4,754,386 32,092,000 0.38%
53 DURATA THERAPEUTICS INC 1,785,714 30,411,000 0.36%
54 EXACT SCIENCES CORP 1,723,000 29,343,000 0.34%
55 ARRAY BIOPHARMA INC 6,402,800 29,197,000 0.34%
56 INCYTE CORP SR NT CONV 4.750% 10/01/15 B/EDTD 03/30/10 0221 UBS FINANCIAL SERVICES INC. A/C MR06471 4,242,000 27,000,000 0.32% PRN
57 Medtronic Inc 423,300 26,990,000 0.32%
58 XENOPORT INC 5,546,100 26,788,000 0.31%
59 LILLY ELI & CO 400,000 24,868,000 0.29%
60 MIRATI THERAPEUTICS INC COM 1,172,000 23,440,000 0.28%
61 JAZZ PHARMACEUTICALS PLC 150,000 22,052,000 0.26% Call
62 ALKERMES PLC 433,300 21,808,000 0.26%
63 FLUIDIGM CORP DEL 21,935,000 20,992,000 0.25% PRN
64 QIAGEN NV 781,400 19,105,000 0.22%
65 CARDINAL HEALTH INC 277,000 18,991,000 0.22%
66 NPS Pharmaceuticals, Inc. 550,200 18,184,000 0.21%
67 CERUS CORP 4,238,000 17,588,000 0.21%
68 VALEANT PHARMACEUTICALS INTL 138,000 17,405,000 0.20%
69 JAZZ PHARMACEUTICALS PLC 115,000 16,906,000 0.20%
70 FIVE PRIME THERAPEUTICS INC 1,075,400 16,722,000 0.20%
71 COVIDIEN PLC 180,600 16,287,000 0.19%
72 PUMA BIOTECHNOLOGY 218,100 14,395,000 0.17%
73 MEI PHARMA INC 1,924,500 12,201,000 0.14%
74 SYNAGEVA BIOPHARMA CORP 111,100 11,643,000 0.14%
75 Questcor 125,000 11,561,000 0.14%
76 Questcor 125,000 11,561,000 0.14% Put
77 AGENUS INC 3,586,100 11,547,000 0.14%
78 NXSTAGE MED INC COM 795,200 11,427,000 0.13%
79 NUVASIVE INC 316,000 11,240,000 0.13%
80 XOMA CORP DEL 2,437,000 11,186,000 0.13%
81 INSMED INC 538,500 10,759,000 0.13%
82 REDHILL BIOPHARMA LTD 605,800 10,595,000 0.12%
83 MERGE HEALTHCARE INC 4,628,500 10,507,000 0.12%
84 AMBIT BIOSCIENCES CORP 1,490,769 10,301,000 0.12%
85 PERNIX THERAPEUTICS HLDGS IN 1,130,600 10,153,000 0.12%
86 INSPIREMD INC 3,395,000 10,015,000 0.12%
87 FOREST LABS INC COM 97,000 9,603,000 0.11%
88 XENCOR INC COM 801,700 9,316,000 0.11%
89 Questcor 100,000 9,249,000 0.11% Call
90 SINOVAC BIOTECH LTD 1,637,500 9,236,000 0.11%
91 ALIMERA SCIENCES INC 1,500,000 8,970,000 0.11%
92 ArQule Inc 5,702,000 8,838,000 0.10%
93 ST JUDE MED INC 125,000 8,656,000 0.10% Call
94 HORIZON PHARMA PLC 546,000 8,638,000 0.10%
95 Sunesis Pharmaceuticals I 1,200,000 7,824,000 0.09%
96 ZOETIS INC 229,000 7,390,000 0.09%
97 ABBOTT LABS 180,000 7,362,000 0.09%
98 VANDA PHARMACEUTICALS INC COM 455,000 7,362,000 0.09%
99 FLUIDIGM CORP DEL COM 250,000 7,350,000 0.09% Call
100 AETNA INC NEW 80,000 6,486,000 0.08%
Page 2 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001172661-14-001491, filed 2014.08.14).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.