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Institutional Investment Manager
ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC (CIK: 0001055951) incorporated in Delaware, located at 601 Lexington Avenue, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q1)
Portfolio Summary: 141 holdings with a total value of $9,503,629,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 AMARIN CORP PLC 350,000 536,000 0.01%
2 BIOMARIN PHARMACEUTICAL INC 0.75 10/15/2018 500,000 579,000 0.01% PRN
3 BIOMARIN PHARMACEUTICAL INC SR SB CONV NT 20 500,000 594,000 0.01% PRN
4 QLT INC 500,000 995,000 0.01%
5 BIOLINERX LTD 1,038,600 1,059,000 0.01%
6 COGENTIX MED INC 990,745 1,090,000 0.01%
7 PERNIX THERAPEUTICS HLDGS IN 1,073,000 1,127,000 0.01%
8 FATE THERAPEUTICS INC 692,900 1,247,000 0.01%
9 XTANT MED HLDGS INC 475,439 1,288,000 0.01%
10 ACHILLION PHARMACEUTICALS IN 200,000 1,544,000 0.02% Call
11 MEDIGUS LTD 600,000 1,608,000 0.02%
12 PORTOLA PHARMACEUTICALS INC 100,000 2,040,000 0.02% Put
13 OREXIGEN THERAPEUTICS INC 5,210,000 2,149,000 0.02% PRN
14 UNIQURE NV 184,800 2,195,000 0.02%
15 ROKA BIOSCIENCE INC 3,220,429 2,222,000 0.02%
16 ALIMERA SCIENCES INC 1,500,000 2,625,000 0.03%
17 Anacor Pharmaceuticals Inc 53,300 2,849,000 0.03%
18 MYLAN N V 69,800 3,235,000 0.03%
19 CERUS CORP 578,300 3,429,000 0.04%
20 ADAPTIMMUNE THERAPEUTICS PLC 438,784 3,567,000 0.04%
21 Ascendis Pharma 222,223 4,122,000 0.04%
22 MIRATI THERAPEUTICS INC COM 197,859 4,234,000 0.04%
23 SERES THERAPEUTICS INC 166,645 4,426,000 0.05%
24 CONNECTURE INC 1,740,000 4,454,000 0.05%
25 INVITAE CORP 456,666 4,672,000 0.05%
26 VALEANT PHARMACEUTICALS INTL 194,900 5,126,000 0.05%
27 Marinus Pharmaceuticals Inc 965,000 5,192,000 0.05%
28 LION BIOTECHNOLOGIES INC COM 1,022,100 5,192,000 0.05%
29 FLUIDIGM CORP DEL 10,000,000 5,553,000 0.06% PRN
30 QIAGEN NV 256,800 5,737,000 0.06%
31 ADVAXIS INC COM NEW 636,600 5,748,000 0.06%
32 MACROGENICS INC 317,000 5,944,000 0.06%
33 SYNERGY PHARMACEUTICALS DEL 2,276,648 6,284,000 0.07%
34 INCYTE CORP SR CV NT0.375 18 4,250,000 6,574,000 0.07% PRN
35 INCYTE CORP 4,250,000 6,727,000 0.07% PRN
36 REDHILL BIOPHARMA LTD 564,900 6,920,000 0.07%
37 ASSEMBLY BIOSCIENCES INC 1,397,100 7,013,000 0.07%
38 Biotie Therapies Corp. 268,672 7,090,000 0.07%
39 ENANTA PHARMACEUTICALS INC 249,400 7,325,000 0.08%
40 ULTRAGENYX PHARMACEUTICAL INC COM 128,300 8,123,000 0.09%
41 INTRA-CELLULAR THERAPIES INC 294,000 8,173,000 0.09%
42 AETNA INC NEW 76,000 8,539,000 0.09%
43 SIENTRA INC 1,357,500 9,285,000 0.10%
44 IMMUNOMEDICS INCORPORATED 3,802,000 9,505,000 0.10%
45 GALAPAGOS NV 230,000 9,619,000 0.10%
46 CELLECTIS S A 350,000 9,625,000 0.10%
47 ABBOTT LABS 237,000 9,914,000 0.10%
48 Syndax Pharmaceuticals Inc 757,365 10,088,000 0.11%
49 EDWARDS LIFESCIENCES CORP 115,000 10,144,000 0.11%
50 INOTEK PHARMACEUTICALS CORP 1,391,000 10,293,000 0.11%
Page 1 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001172661-16-003439, filed 2016.05.16).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.