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Institutional Investment Manager
BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP (CIK: 0001263508) incorporated in Delaware, located at 860 Washington Street, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q4)
Portfolio Summary: 133 holdings with a total value of $10,200,965,000.
#
Name
Shares
Value ($)
%
Options
Notes
101 BLUEBIRD BIO INC COM 351,441 21,684,000 0.21%
102 ARRAY BIOPHARMA INC 2,585,913 22,730,000 0.22%
103 XENCOR INC COM 872,072 22,953,000 0.23%
104 Merus NV 1,160,014 24,488,000 0.24%
105 ACORDA THERAPEUTICS INC 35,083,000 26,570,000 0.26% PRN
106 Progenics Pharmaceuticals Inc 3,150,808 27,223,000 0.27%
107 FOAMIX PHARMACEUTICALS LTD 2,466,702 27,380,000 0.27%
108 VERSARTIS INC 1,920,845 28,621,000 0.28%
109 HERON THERAPEUTICS INC COM 2,383,569 31,225,000 0.31%
110 NEUROCRINE BIOSCIE COM USD0.001 895,422 34,653,000 0.34%
111 EXELIXIS INC 3,003,569 44,783,000 0.44%
112 CERUS CORP 13,053,275 56,782,000 0.56%
113 INVITAE CORP 7,288,300 57,869,000 0.57%
114 ADVANCED ACCELERATOR APPLIC 2,167,137 57,993,000 0.57%
115 ACHAOGEN INC COM 4,582,382 59,663,000 0.58%
116 ACORDA THERAPEUTICS INC 3,301,791 62,074,000 0.61%
117 SPARK THERAPEUTICS INCORPORATED 1,318,341 65,785,000 0.64%
118 BELLICUM PHARMACEUTICALS INCORPORATED 4,865,647 66,270,000 0.65%
119 AMARIN CORP PLC 22,169,509 68,282,000 0.67%
120 BIOCRYST PHARMACEUTICALS 10,963,944 69,402,000 0.68%
121 BIOMARIN PHARMACEUTICAL INC SR SB CV1.875 17 22,379,000 90,531,000 0.89% PRN
122 ABBVIE INC 1,685,994 105,577,000 1.03%
123 BEIGENE LTD 3,673,175 111,518,000 1.09%
124 AQUINOX PHARMACEUTICALS INC 10,536,092 173,951,000 1.71%
125 DBV TECHNOLOGIES S A 5,509,560 193,551,000 1.90%
126 BIOMARIN PHARMACEUTICAL INC 4,806,483 398,169,000 3.90%
127 GENOMIC HEALTH INC COM 13,770,302 404,709,000 3.97%
128 Incyte Corporation 259,000,000 518,139,000 5.08% PRN
129 Incyte Corporation 274,500,000 558,650,000 5.48% PRN
130 ACADIA PHARMACEUTICALS INC COM 25,819,768 744,642,000 7.30%
131 ALEXION PHARMACEUTIC 6,543,295 800,572,000 7.85%
132 INCYTE CORP 23,499,087 2,356,253,000 23.10%
133 SEATTLE GENETICS INC 45,711,856 2,412,215,000 23.65%
Page 3 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-17-008836, filed 2017.02.14).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.