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Institutional Investment Manager
BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP (CIK: 0001263508) incorporated in Delaware, located at 860 Washington Street, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q4)
Portfolio Summary: 133 holdings with a total value of $10,200,965,000.
#
Name
Shares
Value ($)
%
Options
Notes
101 MYOKARDIA INC 100,000 1,295,000 0.01%
102 UNIQURE NV 230,000 1,288,000 0.01%
103 SERES THERAPEUTICS INC 125,000 1,238,000 0.01%
104 COLUCID PHARMACEUTICALS ORD 30,310 1,103,000 0.01%
105 RITTER PHARMACEUTICALS INC 400,000 1,084,000 0.01%
106 ProQR Therapeutics NV 212,698 1,042,000 0.01%
107 MEDIWOUND ORD 226,000 1,035,000 0.01%
108 PALATIN TECHNOLOGIES INC COM 2,050,000 1,035,000 0.01%
109 FIVE PRIME THERAPEUTICS INC 19,247 964,000 0.01%
110 MADRIGAL PHARMACEUTICALS INC 57,762 861,000 0.01%
111 CELLECTIS S A 50,000 848,000 0.01%
112 TENAX THERAPEUTICS INC 420,000 819,000 0.01%
113 IMMUNE DESIGN CORP 148,937 819,000 0.01%
114 INFINITY PHARMACEUTICALS INC 580,400 784,000 0.01%
115 Aldeyra Therapeutics Inc 142,000 760,000 0.01%
116 Proteon Therapeutics Inc 389,394 740,000 0.01%
117 ACCELERON PHARMA INC 28,765 734,000 0.01%
118 AFFIMED N V COM 400,000 720,000 0.01%
119 CYMABAY THERAPEUTICS INC 309,268 535,000 0.01%
120 CHIMERIX INC 115,216 530,000 0.01%
121 ARBUTUS BIOPHARMA CORP 180,582 442,000 0.00%
122 ALNYLAM PHARMACEUTICALS INC 11,340 425,000 0.00%
123 ADAPTIMMUNE THERAPEUTICS PLC 100,000 405,000 0.00%
124 Foundation Medicine 20,892 370,000 0.00%
125 BIODELIVERY SCIENCES INTL IN 210,021 368,000 0.00%
126 CHEMOCENTRYX INC 49,064 363,000 0.00%
127 APTOSE BIOSCIENCES INC 258,311 359,000 0.00%
128 WINDTREE THERAPEUTICS INC 254,973 319,000 0.00%
129 Sierra Oncology, Inc. 200,000 298,000 0.00%
130 DYNAVAX TECHNOLOGIES CORP 75,000 296,000 0.00%
131 LA JOLLA PHARMACEUTICAL CO 13,746 241,000 0.00%
132 CYCLACEL PHARMACEUTICALS INC 13,253 82,000 0.00%
133 BIOTIME INC 20,084 14,000 0.00%
Page 3 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-17-008836, filed 2017.02.14).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.