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Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2015Q3)
Portfolio Summary: 127 holdings with a total value of $783,792,000.
#
Name
Shares
Value ($)
%
Options
Notes
51 ALNYLAM PHARMACEUTICALS INC 40,000 3,214,000 0.41%
52 FORWARD PHARMA A/S 135,000 3,181,000 0.41%
53 KITE PHARMA INCORPORATED 56,970 3,172,000 0.40%
54 CARA THERAPEUTICS INC 219,800 3,141,000 0.40%
55 Arrowhead Pharma Inc 540,000 3,110,000 0.40%
56 ARBUTUS BIOPHARMA CORP 505,000 3,075,000 0.39%
57 INSMED INC 165,000 3,064,000 0.39%
58 CYNAPSUS THERAPEUTICS INC 188,930 3,059,000 0.39%
59 RETROPHIN INC 150,000 3,039,000 0.39%
60 THERAPEUTICSMD INC 512,500 3,003,000 0.38%
61 TJX COS INC NEW 41,496 2,964,000 0.38%
62 ULTRAGENYX PHARMACEUTICAL INC COM 30,700 2,957,000 0.38%
63 SPARK THERAPEUTICS INCORPORATED 70,000 2,921,000 0.37%
64 INTERCEPT PHARMACEUTICALS INCORPORATED 17,500 2,903,000 0.37%
65 VALEANT PHARMACEUTICALS INTL 15,750 2,809,000 0.36%
66 EXELIXIS INC 500,000 2,805,000 0.36%
67 FOAMIX PHARMACEUTICALS LTD 380,000 2,785,000 0.36%
68 INOTEK PHARMACEUTICALS CORP 295,000 2,773,000 0.35%
69 MIRATI THERAPEUTICS INC COM 80,000 2,754,000 0.35%
70 IONIS PHARMACEUTICAL 68,000 2,749,000 0.35%
71 PALATIN TECHNOLOGIES INC COM 3,358,483 2,720,000 0.35%
72 FIVE PRIME THERAPEUTICS INC 175,000 2,693,000 0.34%
73 Nivalis Therapeutics Inc 201,720 2,616,000 0.33%
74 Catabasis Pharmaceuticals Inc 327,476 2,595,000 0.33%
75 GENOCEA BIOSCIENCES INC 377,200 2,584,000 0.33%
76 Biotie Therapies Corp. 196,800 2,576,000 0.33%
77 CYTOKINETICS INC 372,250 2,490,000 0.32%
78 MONDELEZ INTL INC 59,475 2,490,000 0.32%
79 ACCELERON PHARMA INC 100,000 2,490,000 0.32%
80 KERYX BIOPHARMACEUTICALS INCORPORATED 700,000 2,464,000 0.31%
81 DYNAVAX TECHNOLOGIES CORP 100,000 2,454,000 0.31%
82 ABEONA THERAPEUTICS INC 600,000 2,430,000 0.31%
83 PARTNER COMMUNICATIONS 617,951 2,416,000 0.31%
84 UNIQURE NV 115,000 2,352,000 0.30%
85 ELLOMAY CAPITAL LIMITED 221,097 2,335,000 0.30%
86 SCYNEXIS INC 313,000 2,279,000 0.29%
87 Life Technologies Corp 209,027 2,145,000 0.27%
88 SUMMIT THERAPEUTICS PLC 205,200 2,136,000 0.27%
89 CEMPRA INC 75,000 2,088,000 0.27%
90 IMMUNE DESIGN CORP 170,000 2,074,000 0.26%
91 PROTHENA CORP PLC 45,133 2,046,000 0.26%
92 AEGERION PHARMACEUTICALS INC 150,000 2,040,000 0.26%
93 HALOZYME THERAPEUTICS INC 150,000 2,015,000 0.26%
94 WABTEC CORP 22,735 2,002,000 0.26%
95 RELYPSA INC 107,000 1,981,000 0.25%
96 EPIZYME INC COM 150,000 1,929,000 0.25%
97 SEATTLE GENETICS INC 50,000 1,928,000 0.25%
98 TRILLIUM THERAPEUTICS INC 147,000 1,915,000 0.24%
99 NOVARTIS A G 20,000 1,838,000 0.23%
100 SAREPTA THERAPEUTICS INC 55,000 1,766,000 0.23%
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Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001178913-15-003433, filed 2015.11.16).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.