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Institutional Investment Manager
Opaleye Management Inc.
Opaleye Management Inc. (CIK: 0001595855) incorporated in Massachusetts, located at One Boston Place, Boston, MA. Institutional holdings reported to the SEC.

Institutional Holdings (2014Q4)
Portfolio Summary: 36 holdings with a total value of $197,898,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 BIOLINERX LTD 250,000 405,000 0.20%
2 CARA THERAPEUTICS INC 80,000 798,000 0.40%
3 NEUROCRINE BIOSCIE COM USD0.001 45,000 1,005,000 0.51%
4 EVOKE PHARMA INC 240,000 1,416,000 0.72%
5 TENAX THERAPEUTICS INC 440,000 1,690,000 0.85%
6 CELGENE CORP 575,000 1,811,000 0.92%
7 ACCELERATE DIAGNOSTICS INC 100,000 1,919,000 0.97%
8 ALNYLAM PHARMACEUTICALS INC 29,100 2,823,000 1.43%
9 HORIZON PHARMA PLC 220,000 2,836,000 1.43%
10 CATALYST PHARMACEUTICALS INC 975,000 2,896,000 1.46%
11 SUPERNUS PHARMACEUTICALS INC 350,000 2,905,000 1.47%
12 TRILLIUM THERAPEUTICS INC 333,333 3,000,000 1.52%
13 PARATEK PHARMACEUTICALS INC 80,000 3,084,000 1.56%
14 FLUIDIGM CORP DEL COM 95,000 3,204,000 1.62%
15 FLAMEL TECHNOLOGIES SA SPONSORED ADR 205,000 3,512,000 1.77%
16 CARDIOVASCULAR SYS INC DEL COM 125,000 3,760,000 1.90%
17 ONCOTHYREON INC 2,000,000 3,800,000 1.92%
18 IMPRIMIS PHARMACEUTICALS INC 560,000 4,200,000 2.12%
19 MEDGENICS INC 850,000 4,301,000 2.17%
20 Codexis Inc Com 1,724,000 4,344,000 2.20%
21 KITE PHARMA INCORPORATED 76,000 4,383,000 2.21%
22 OPHTHOTECH CORP 100,000 4,487,000 2.27%
23 GENMARK DIAGNOSTICS INC. 335,000 4,559,000 2.30%
24 ULTRAGENYX PHARMACEUTICAL INC COM 106,200 4,660,000 2.35%
25 INSYS THERAPEUTICS INC NEW COM NEW 122,500 5,165,000 2.61%
26 FIBROGEN INC 191,338 5,231,000 2.64%
27 VERSARTIS INC 235,000 5,276,000 2.67%
28 GERON CORP 1,825,000 5,931,000 3.00%
29 TETRAPHASE PHARMACEUTICALS INC COM 189,700 7,533,000 3.81%
30 CLOVIS ONCOLOGY INC 140,000 7,840,000 3.96%
31 PHARMACYCLICS INC 85,000 10,392,000 5.25%
32 ARIAD PHARMACEUTICALS ORD (NMS) 1,525,000 10,477,000 5.29%
33 RETROPHIN INC 920,000 11,261,000 5.69%
34 CEMPRA INC 504,800 11,868,000 6.00%
35 AGIOS PHARMACEUTICALS INC 113,500 12,717,000 6.43%
36 CHIMERIX INC 805,000 32,409,000 16.38%

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001546927-15-000070, filed 2015.02.13).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.