Dark
Light
System
Institutional Investment Manager
ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC (CIK: 0001055951) incorporated in Delaware, located at 601 Lexington Avenue, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2015Q4)
Portfolio Summary: 130 holdings with a total value of $11,043,258,000.
#
Name
Shares
Value ($)
%
Options
Notes
51 DYNAVAX TECHNOLOGIES CORP 2,472,200 59,728,000 0.54%
52 SHIRE PLC 250,971 51,449,000 0.47%
53 Otonomy Inc 1,850,094 51,340,000 0.46%
54 MEDTRONIC PLC 588,299 45,252,000 0.41%
55 ARRAY BIOPHARMA INC 10,689,000 45,108,000 0.41%
56 CIGNA CORPORATION 282,000 41,265,000 0.37%
57 CERUS CORP 6,504,400 41,108,000 0.37%
58 VALEANT PHARMACEUTICALS INTL 390,000 39,644,000 0.36%
59 NEWLINK GENETICS CORP COM 955,306 34,764,000 0.31%
60 INFINITY PHARMACEUTICALS INC 4,416,300 34,668,000 0.31%
61 MOLINA HEALTHCARE INC 568,850 34,205,000 0.31%
62 AFFIMED N V COM 4,582,616 32,628,000 0.30%
63 XENOPORT INC 5,768,400 31,669,000 0.29%
64 JOHNSON & JOHNSON 292,000 29,994,000 0.27%
65 Sierra Oncology, Inc. 1,989,949 29,929,000 0.27%
66 UNITEDHEALTH GROUP INC 238,000 27,998,000 0.25%
67 FLUIDIGM CORP DEL COM 2,449,900 26,483,000 0.24%
68 CLOVIS ONCOLOGY INC 729,600 25,536,000 0.23%
69 GW PHARMACEUTICALS PLC 304,100 21,117,000 0.19%
70 ProQR Therapeutics NV 2,271,500 19,717,000 0.18%
71 FORWARD PHARMA A/S 960,600 18,251,000 0.17%
72 CYNAPSUS THERAPEUTICS INC 1,140,325 17,604,000 0.16%
73 STRYKER CORP 186,000 17,287,000 0.16%
74 ENANTA PHARMACEUTICALS INC 504,300 16,652,000 0.15%
75 Pieris Pharmaceuticals 7,259,620 16,625,000 0.15%
76 XENCOR INC COM 1,107,022 16,185,000 0.15%
77 BIOMARIN PHARMACEUTICAL INC 149,000 15,609,000 0.14%
78 SINOVAC BIOTECH LTD 2,667,500 15,258,000 0.14%
79 ZIMMER BIOMET HLDGS INC 146,800 15,060,000 0.14%
80 GALAPAGOS NV 230,000 14,462,000 0.13%
81 Natera, Inc. 1,276,190 13,783,000 0.12%
82 CARDINAL HEALTH INC 146,000 13,033,000 0.12%
83 EHEALTH INC COM 1,300,000 12,974,000 0.12%
84 SYNERGY PHARMACEUTICALS DEL 2,276,648 12,909,000 0.12%
85 ADR - Nabriva Therapeutics AG- Usd 1,315,000 12,650,000 0.11%
86 JAZZ PHARMACEUTICALS PLC 90,000 12,650,000 0.11%
87 IMMUNOMEDICS INCORPORATED 3,802,000 11,672,000 0.11%
88 ENSIGN GROUP INC 495,200 11,206,000 0.10%
89 BAXALTA INC COM 285,000 11,124,000 0.10%
90 CELLECTIS S A 350,000 10,861,000 0.10%
91 ASSEMBLY BIOSCIENCES INC 1,397,100 10,492,000 0.10%
92 MACROGENICS INC 317,000 9,817,000 0.09%
93 ABBOTT LABS 211,000 9,476,000 0.09%
94 INCYTE CORP 4,250,000 9,292,000 0.08% PRN
95 INCYTE CORP SR CV NT0.375 18 4,250,000 9,195,000 0.08% PRN
96 VITAE PHARMACEUTICALS INC 487,400 8,822,000 0.08%
97 SIENTRA INC 1,357,500 8,036,000 0.07%
98 LION BIOTECHNOLOGIES INC COM 1,022,100 7,891,000 0.07%
99 MEDIVATION INC 163,000 7,879,000 0.07%
100 Marinus Pharmaceuticals Inc 965,000 7,373,000 0.07%
Page 2 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001172661-16-002937, filed 2016.02.16).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.