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Institutional Investment Manager
BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP (CIK: 0001263508) incorporated in Delaware, located at 860 Washington Street, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q2)
Portfolio Summary: 135 holdings with a total value of $9,537,918,000.
#
Name
Shares
Value ($)
%
Options
Notes
101 MAST THERAPEUTICS INC COM 3,868,026 1,818,000 0.02%
102 MEDIWOUND ORD 226,000 1,783,000 0.02%
103 AMARIN CORP PLC 801,860 1,732,000 0.02%
104 UNIQURE NV 230,000 1,695,000 0.02%
105 ENANTA PHARMACEUTICALS INC 75,357 1,662,000 0.02%
106 CYTRX CORP 659,995 1,472,000 0.02%
107 KARYOPHARM THERAPEUTICS INC COM 216,990 1,456,000 0.02%
108 ASSEMBLY BIOSCIENCES INC 250,000 1,388,000 0.01%
109 GW PHARMACEUTICALS PLC 15,000 1,374,000 0.01%
110 IONIS PHARMACEUTICALS INC COM 57,140 1,331,000 0.01%
111 CELLECTIS S A 50,000 1,330,000 0.01%
112 IMMUNE DESIGN CORP 148,937 1,215,000 0.01%
113 DYNAVAX TECHNOLOGIES CORP 75,000 1,094,000 0.01%
114 TENAX THERAPEUTICS INC 420,000 1,075,000 0.01%
115 SCYNEXIS INC 467,600 1,015,000 0.01%
116 AFFIMED N V COM 400,000 992,000 0.01%
117 ACCELERON PHARMA INC 28,765 977,000 0.01%
118 PALATIN TECHNOLOGIES INC COM 2,050,000 905,000 0.01%
119 ADAPTIMMUNE THERAPEUTICS PLC 100,000 815,000 0.01%
120 Aldeyra Therapeutics Inc 142,000 808,000 0.01%
121 FIVE PRIME THERAPEUTICS INC 19,247 796,000 0.01%
122 ALNYLAM PHARMACEUTICALS INC 11,340 629,000 0.01%
123 ARBUTUS BIOPHARMA CORP 180,582 628,000 0.01%
124 RITTER PHARMACEUTICALS INC 400,000 612,000 0.01%
125 SYNTA PHARMACEUTICALS CORP 2,021,728 526,000 0.01%
126 BIODELIVERY SCIENCES INTL IN 210,021 496,000 0.01%
127 WINDTREE THERAPEUTICS INC 254,973 492,000 0.01%
128 CHIMERIX INC 115,216 453,000 0.00%
129 Sierra Oncology, Inc. 200,000 398,000 0.00%
130 Foundation Medicine 20,892 390,000 0.00%
131 ACHAOGEN INC COM 100,000 379,000 0.00%
132 LA JOLLA PHARMACEUTICAL CO 13,746 220,000 0.00%
133 CHEMOCENTRYX INC 49,064 220,000 0.00%
134 CYCLACEL PHARMACEUTICALS INC 13,253 83,000 0.00%
135 BIOTIME INC 20,084 9,000 0.00%
Page 3 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-16-119409, filed 2016.08.15).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.