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Institutional Investment Manager
ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC (CIK: 0001055951) incorporated in Delaware, located at 601 Lexington Avenue, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2015Q2)
Portfolio Summary: 136 holdings with a total value of $11,964,202,000.
#
Name
Shares
Value ($)
%
Options
Notes
51 CONNECTURE INC 1,740,000 18,374,000 0.15%
52 Pieris Pharmaceuticals 7,259,620 19,964,000 0.17%
53 ABBVIE INC 300,000 20,157,000 0.17% Call
54 JAZZ PHARMACEUTICALS PLC 115,000 20,248,000 0.17%
55 MIRATI THERAPEUTICS INC COM 680,500 21,415,000 0.18%
56 XENCOR INC COM 1,044,615 22,950,000 0.19%
57 ZIMMER BIOMET HLDGS INC 212,300 23,190,000 0.19%
58 CYNAPSUS THERAPEUTICS INC 1,140,325 23,274,000 0.19%
59 MERCK & CO INC 415,000 23,626,000 0.20%
60 Ascendis Pharma 1,448,991 25,618,000 0.21%
61 BIOMARIN PHARMACEUTICAL INC 188,000 25,715,000 0.21%
62 SYNERGY PHARMACEUTICALS DEL 3,121,148 25,906,000 0.22%
63 GALAPAGOS NV 512,900 26,414,000 0.22%
64 ASSEMBLY BIOSCIENCES INC 1,397,100 26,908,000 0.22%
65 UNITEDHEALTH GROUP INC 238,000 29,036,000 0.24%
66 DYAX CORP COM CVR 1,117,000 29,601,000 0.25%
67 ProQR Therapeutics NV 1,831,400 30,529,000 0.26%
68 ADURO BIOTECH INC 1,065,522 32,317,000 0.27%
69 INCYTE CORP SR NT CONV 4.750% 10/01/15 B/EDTD 03/30/10 0221 UBS FINANCIAL SERVICES INC. A/C MR06471 2,742,000 32,436,000 0.27% PRN
70 HORIZON PHARMA PLC 951,000 33,038,000 0.28%
71 BRISTOL MYERS SQUIBB CO 500,000 33,270,000 0.28% Call
72 XENOPORT INC 5,768,400 35,360,000 0.30%
73 FORWARD PHARMA A/S 960,600 36,551,000 0.31%
74 VALEANT PHARMACEUTICALS INTL 165,000 36,655,000 0.31%
75 PORTOLA PHARMACEUTICALS INC 850,700 38,749,000 0.32%
76 LOXO ONCOLOGY INC COM 2,175,857 39,231,000 0.33%
77 GW PHARMACEUTICALS PLC 325,000 39,923,000 0.33%
78 SPDR S&P 500 ETF TR 200,000 41,170,000 0.34% Put
79 INSMED INC 1,708,500 41,722,000 0.35%
80 CERUS CORP 8,307,727 43,117,000 0.36%
81 CHIMERIX INC 1,021,600 47,198,000 0.39%
82 MEDTRONIC PLC 646,300 47,891,000 0.40%
83 INFINITY PHARMACEUTICALS INC 4,416,300 48,358,000 0.40%
84 Otonomy Inc 2,256,398 51,875,000 0.43%
85 EXACT SCIENCES CORP 1,778,000 52,878,000 0.44%
86 FLUIDIGM CORP DEL COM 2,449,900 59,288,000 0.50%
87 JOHNSON & JOHNSON 617,000 60,133,000 0.50%
88 NUVASIVE INC 1,487,000 70,454,000 0.59%
89 ARRAY BIOPHARMA INC 10,060,500 72,536,000 0.61%
90 AFFIMED N V COM 5,814,630 78,323,000 0.65%
91 SIENTRA INC 3,185,306 80,365,000 0.67%
92 ADAPTIMMUNE THERAPEUTICS PLC 4,411,186 80,857,000 0.68%
93 AFFYMETRIX INCOC-CAP STK CASH MGREFF 4/1/16 1 OLDUSD 14.00 PER SHARE 7,511,000 82,020,000 0.69%
94 GLAUKOS CORP 2,897,937 83,982,000 0.70%
95 OPHTHOTECH CORP 1,674,600 87,180,000 0.73%
96 WRIGHT MEDICAL GROUP NV 3,337,000 87,630,000 0.73%
97 CLOVIS ONCOLOGY INC 1,005,200 88,337,000 0.74%
98 MALLINCKRODT PUB LTD CO 795,000 93,587,000 0.78%
99 INSYS THERAPEUTICS INC NEW COM NEW 2,623,000 94,218,000 0.79%
100 COMMUNITY HEALTH SYS INC NEW 1,530,000 96,344,000 0.81%
Page 2 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001172661-15-001654, filed 2015.08.14).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.