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Institutional Investment Manager
BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP (CIK: 0001263508) incorporated in Delaware, located at 860 Washington Street, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2015Q4)
Portfolio Summary: 133 holdings with a total value of $12,071,272,000.
#
Name
Shares
Value ($)
%
Options
Notes
101 ENANTA PHARMACEUTICALS INC 75,357 2,488,000 0.02%
102 PROTALIX BIOTHERAPEUTICS INC 3,423,000 2,375,000 0.02% PRN
103 OHR PHARMACEUTICAL INC 370,370 2,274,000 0.02%
104 STEMLINE THERAPEUTICS INC 333,497 2,104,000 0.02%
105 MAST THERAPEUTICS INC COM 4,797,442 2,016,000 0.02%
106 IRONWOOD PHARMACEUTICALS INC 169,163 1,961,000 0.02%
107 MEDIWOUND ORD 225,000 1,922,000 0.02%
108 ASSEMBLY BIOSCIENCES INC 250,000 1,878,000 0.02%
109 DYNAVAX TECHNOLOGIES CORP 75,000 1,812,000 0.02%
110 AURINIA PHARMACEUTICALS INC 711,499 1,789,000 0.01%
111 CYTRX CORP 659,995 1,749,000 0.01%
112 CELLECTIS S A 50,000 1,552,000 0.01%
113 Marinus Pharmaceuticals Inc 200,000 1,528,000 0.01%
114 ACCELERON PHARMA INC 28,765 1,403,000 0.01%
115 TENAX THERAPEUTICS INC 420,000 1,378,000 0.01%
116 PALATIN TECHNOLOGIES INC COM 2,050,000 1,361,000 0.01%
117 ADAPTIMMUNE THERAPEUTICS PLC 100,000 1,206,000 0.01%
118 ALNYLAM PHARMACEUTICALS INC 11,340 1,068,000 0.01%
119 CHIMERIX INC 115,216 1,031,000 0.01%
120 BIODELIVERY SCIENCES INTL IN 210,021 1,006,000 0.01%
121 Aldeyra Therapeutics Inc 142,000 963,000 0.01%
122 ARBUTUS BIOPHARMA CORP 180,582 804,000 0.01%
123 FIVE PRIME THERAPEUTICS INC 19,247 799,000 0.01%
124 DISCOVERY LABORATORIES INC N 3,569,643 764,000 0.01%
125 RITTER PHARMACEUTICALS INC 400,000 680,000 0.01%
126 ACHAOGEN INC COM 100,000 574,000 0.00%
127 UNIQURE NV 30,000 496,000 0.00%
128 Foundation Medicine 20,892 440,000 0.00%
129 CHEMOCENTRYX INC 49,064 397,000 0.00%
130 LA JOLLA PHARMACEUTICAL CO 13,746 371,000 0.00%
131 APTOSE BIOSCIENCES INC 33,397 84,000 0.00%
132 CYCLACEL PHARMACEUTICALS INC 13,253 52,000 0.00%
133 BIOTIME INC 20,084 24,000 0.00%
Page 3 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-16-082790, filed 2016.02.16).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.