| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Marinus Pharmaceuticals Inc | 63,517 | 81,000 | 0.01% | ||
| 2 | UNIQURE NV | 20,453 | 151,000 | 0.01% | ||
| 3 | ZOGENIX INC | 29,500 | 237,000 | 0.02% | ||
| 4 | OREXIGEN THERAPEUTICS INC COM | 1,673,024 | 719,000 | 0.05% | ||
| 5 | HISTOGENICS CORP | 454,545 | 777,000 | 0.06% | ||
| 6 | DICERNA PHARMACEUTICALS INC | 267,890 | 804,000 | 0.06% | ||
| 7 | SOPHIRIS BIO INC | 494,000 | 1,062,000 | 0.08% | ||
| 8 | INTREXON CORPORATION | 47,100 | 1,159,000 | 0.09% | ||
| 9 | CYTOKINETICS INC | 123,686 | 1,174,000 | 0.09% | ||
| 10 | ALCOBRA LTD | 272,788 | 1,225,000 | 0.09% | ||
| 11 | IDERA PHARMACEUTICALS INCORPORATED COM NEW | 1,257,748 | 1,924,000 | 0.15% | ||
| 12 | ALIGN TECHNOLOGY INC | 36,357 | 2,929,000 | 0.22% | ||
| 13 | AIMMUNE THERAPEUTICS INC COM | 325,599 | 3,523,000 | 0.27% | ||
| 14 | ALIMERA SCIENCES INC | 3,013,793 | 3,707,000 | 0.28% | ||
| 15 | Sunesis Pharmaceuticals I | 6,974,854 | 3,820,000 | 0.29% | ||
| 16 | ACELRX PHARMACEUTICALS INC | 1,425,439 | 3,834,000 | 0.29% | ||
| 17 | EXACT SCIENCES CORP | 396,276 | 4,854,000 | 0.37% | ||
| 18 | SEQUENOM INC | 10,322,377 | 9,432,000 | 0.71% | ||
| 19 | RIGEL PHARMACEUTICAL INC | 5,386,534 | 12,012,000 | 0.91% | ||
| 20 | SAGE THERAPEUTICS INC | 417,878 | 12,591,000 | 0.95% | ||
| 21 | ENDO INTL PLC | 923,230 | 14,393,000 | 1.09% | ||
| 22 | Heartware International, Inc. | 272,986 | 15,765,000 | 1.19% | ||
| 23 | MEDIVATION INC | 273,983 | 16,521,000 | 1.25% | ||
| 24 | MOMENTA PHARMACEUTICALS INC | 1,629,076 | 17,594,000 | 1.33% | ||
| 25 | STAAR Surgical Co | 3,207,210 | 17,672,000 | 1.33% | ||
| 26 | ARIAD PHARMACEUTICALS ORD (NMS) | 2,535,117 | 18,735,000 | 1.42% | ||
| 27 | KARYOPHARM THERAPEUTICS INC COM | 3,139,433 | 21,066,000 | 1.59% | ||
| 28 | AMICUS THERAPEUTICS INC COM | 4,009,375 | 21,891,000 | 1.65% | ||
| 29 | SHIRE PLC | 119,300 | 21,961,000 | 1.66% | ||
| 30 | GILEAD SCIENCES INC | 318,400 | 26,561,000 | 2.01% | ||
| 31 | PROTHENA CORP PLC | 788,618 | 27,570,000 | 2.08% | ||
| 32 | CELGENE CORP | 279,600 | 27,577,000 | 2.08% | ||
| 33 | EPIZYME INC COM | 2,711,381 | 27,765,000 | 2.10% | ||
| 34 | ZELTIQ AESTHETICS INC | 1,391,079 | 38,018,000 | 2.87% | ||
| 35 | ALEXION PHARMACEUTIC | 339,400 | 39,628,000 | 2.99% | ||
| 36 | Wright Medical Group NV | 2,408,393 | 41,834,000 | 3.16% | ||
| 37 | CEMPRA INC | 2,787,542 | 45,967,000 | 3.47% | ||
| 38 | ACADIA PHARMACEUTICALS INC COM | 1,437,730 | 46,669,000 | 3.53% | ||
| 39 | VANDA PHARMACEUTICALS INC COM | 4,225,608 | 47,285,000 | 3.57% | ||
| 40 | INSMED INC | 5,054,713 | 49,839,000 | 3.76% | ||
| 41 | CLOVIS ONCOLOGY INC | 3,804,088 | 52,192,000 | 3.94% | ||
| 42 | AMAG PHARMACEUTICALS INC | 3,273,220 | 78,295,000 | 5.91% | ||
| 43 | BIOMARIN PHARMACEUTICAL INC | 1,737,399 | 135,170,000 | 10.21% | ||
| 44 | UNITED THERAPEUTICS CORP DEL | 1,718,658 | 182,040,000 | 13.75% | ||
| 45 | ABIOMED INC | 2,066,919 | 225,894,000 | 17.06% |
Portfolio data is normalized using SEC Form 13F filings, including the Restatement filing (0001306923-16-000050, filed 2016.08.16).
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
