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Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2014Q3)
Portfolio Summary: 128 holdings with a total value of $809,459,000.
#
Name
Shares
Value ($)
%
Options
Notes
101 IGNYTA INC COM 199,055 1,604,000 0.20%
102 ACELRX PHARMACEUTICALS INC 289,849 1,591,000 0.20%
103 OCERA THERAPEUTICS INC 321,254 1,574,000 0.19%
104 Receptos Inc 25,000 1,553,000 0.19%
105 EPIZYME INC COM 50,000 1,356,000 0.17%
106 CYTOKINETICS INC 363,212 1,279,000 0.16%
107 GENVEC INC 558,325 1,161,000 0.14%
108 AURIS MED HLDG AG 191,300 1,111,000 0.14%
109 BIOBLAST PHARMA LTD 150,000 1,091,000 0.13%
110 PALATIN TECHNOLOGIES INC COM 1,084,466 1,009,000 0.12%
111 AFFIMED N V COM 150,000 945,000 0.12%
112 DISCOVERY LABORATORIES INC N 485,500 893,000 0.11%
113 ALCOBRA LTD 56,100 866,000 0.11% Call
114 ONCOTHYREON INC COM N/C EFF 6/ 428,000 822,000 0.10%
115 ZS PHARMA INC 20,682 811,000 0.10%
116 TETRALOGIC PHARMA CO 194,200 808,000 0.10%
117 PROTHENA CORP PLC 29,907 663,000 0.08%
118 STEMCELLS INC COM NEW 485,500 612,000 0.08%
119 KALOBIOS PHARMACEUTICALS INC 349,560 542,000 0.07%
120 ORMAT TECHNOLOGIES INC 19,889 522,000 0.06%
121 BIOLINERX LTD 193,284 298,000 0.04%
122 CONCERT PHARMACEUTICALS INCORPORATED 22,700 286,000 0.04%
123 BRAINSTORM CELL THERAPEUTICS 63,331 265,000 0.03%
124 SUMMIT FINANCIAL GROUP INC COM 25,000 63,000 0.01%
125 Macrocure Ltd. 7,100 51,000 0.01%
126 TETRAPHASE PHARMACEUTICALS INC COM 2,365 47,000 0.01%
127 AUXILIUM PHARMACEUTICALS INC 1,000 30,000 0.00%
128 AGIOS PHARMACEUTICALS INC 405 25,000 0.00%
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Portfolio data is normalized using SEC Form 13F filings, including the Restatement filing (0001178913-14-003634, filed 2014.11.20).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.