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Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2014Q3)
Portfolio Summary: 128 holdings with a total value of $809,459,000.
#
Name
Shares
Value ($)
%
Options
Notes
51 UNION PAC CORP 32,312 3,503,000 0.43%
52 TOKAI PHARMACEUTICALS INC COM 230,000 3,482,000 0.43%
53 INTERCEPT PHARMACEUTICALS INCORPORATED 14,565 3,447,000 0.43%
54 ProQR Therapeutics NV 200,000 3,438,000 0.42%
55 AERIE PHARMACEUTICALS INC COM 163,516 3,383,000 0.42%
56 CYMABAY THERAPEUTICS INC 490,355 3,354,000 0.41%
57 CVS HEALTH CORP 39,810 3,168,000 0.39%
58 V F CORP 47,900 3,163,000 0.39%
59 RADIUS HEALTH INCORPORATED COM NEW 150,000 3,150,000 0.39%
60 SALIX PHARMACEUTICALS INC 20,000 3,125,000 0.39%
61 SELECT SECTOR SPDR TR 48,853 3,122,000 0.39%
62 ARRAY BIOPHARMA INC 873,922 3,120,000 0.39%
63 ACCELERON PHARMA INC 100,000 3,024,000 0.37%
64 INCYTE CORP 61,173 3,001,000 0.37%
65 AVANIR PHARMACEUTICALS INC CL 250,000 2,980,000 0.37%
66 TJX COS INC NEW 50,000 2,959,000 0.37% Call
67 SCHLUMBERGER LTD 28,790 2,928,000 0.36%
68 YUM BRANDS INC 39,910 2,873,000 0.35%
69 PTC THERAPEUTICS INC 63,625 2,800,000 0.35%
70 TOWERS WATSON & CO 28,000 2,786,000 0.34%
71 SAGE THERAPEUTICS INC 87,924 2,770,000 0.34%
72 Otonomy Inc 111,085 2,666,000 0.33%
73 Nice Systems LTD Sponsored 64,542 2,622,000 0.32%
74 GOOGLE INC 4,540 2,621,000 0.32%
75 COLGATE PALMOLIVE CO 40,099 2,615,000 0.32%
76 IRONWOOD PHARMACEUTICALS INC 194,200 2,516,000 0.31%
77 CATALYST PHARMACEUTICALS INC 685,500 2,276,000 0.28%
78 VANDA PHARMACEUTICALS INC COM 218,390 2,267,000 0.28%
79 MACROGENICS INC 107,781 2,253,000 0.28%
80 ISHARES NASDAQ BIOTECHNOLOGY ETF 3,784 2,227,000 0.28%
81 LA JOLLA PHARMACEUTICAL CO 223,330 2,146,000 0.27%
82 TREVENA INC 331,111 2,126,000 0.26%
83 ARENA PHARMACEUTICALS INC 500,000 2,095,000 0.26%
84 RELYPSA INC 97,100 2,048,000 0.25%
85 AKEBIA THERAPEUTICS INC 89,817 1,988,000 0.25%
86 IMMUNOMEDICS INCORPORATED 534,050 1,987,000 0.25%
87 ACTINIUM PHARMACEUTICALS INC 291,300 1,952,000 0.24%
88 SNAP ON INC 16,100 1,949,000 0.24%
89 CELLADON CORP 185,656 1,942,000 0.24%
90 KITE PHARMA INCORPORATED 67,970 1,937,000 0.24%
91 MASTERCARD INCORPORATED 26,000 1,922,000 0.24%
92 BLUEBIRD BIO INC COM 53,405 1,916,000 0.24%
93 ZAFGEN INC COM 97,100 1,908,000 0.24%
94 Alder Biopharmaceutl 150,000 1,902,000 0.23%
95 Marinus Pharmaceuticals Inc 293,533 1,899,000 0.23%
96 ELLOMAY CAPITAL LIMITED 191,202 1,891,000 0.23%
97 PROSENSA HLDG N V SHS USD 219,345 1,849,000 0.23%
98 ONCOMED PHARMACEUTICALS INC COM 97,100 1,838,000 0.23%
99 MANNKIND CORP 300,000 1,773,000 0.22% Put
100 TJX COS INC NEW 27,600 1,633,000 0.20%
Page 2 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Restatement filing (0001178913-14-003634, filed 2014.11.20).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.