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Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q4)
Portfolio Summary: 104 holdings with a total value of $395,050,000.
#
Name
Shares
Value ($)
%
Options
Notes
51 Aevi Genomic Medicine Inc 450,000 2,331,000 0.59%
52 PORTOLA PHARMACEUTICALS INC 100,000 2,244,000 0.57%
53 KITE PHARMA INCORPORATED 50,000 2,242,000 0.57%
54 ARDELYX INC COM 151,813 2,156,000 0.55%
55 PARATEK PHARMACEUTICALS INC 140,000 2,156,000 0.55%
56 AVEXIS INC COM 45,000 2,148,000 0.54%
57 VistaGen Therapeutics Inc 544,100 2,029,000 0.51%
58 FIVE PRIME THERAPEUTICS INC 40,000 2,004,000 0.51%
59 Aldeyra Therapeutics Inc 368,500 1,971,000 0.50%
60 SNAP ON INC 10,972 1,879,000 0.48%
61 EDGE THERAPEUTICS INC 150,000 1,875,000 0.47%
62 FORWARD PHARMA A/S 121,500 1,824,000 0.46%
63 GLOBAL BLOOD THERAPEUTICS INCORPORATED 125,000 1,806,000 0.46%
64 MACROGENICS INC 81,200 1,660,000 0.42%
65 PTC THERAPEUTICS INC 150,000 1,637,000 0.41%
66 PACIRA PHARMACEUTICALS INC 50,000 1,615,000 0.41%
67 TOWER SEMICONDUCTOR LTD 83,940 1,597,000 0.40%
68 SAPIENS INTL CORP N V SHS NEW 109,322 1,568,000 0.40%
69 COGNIZANT TECHNOLOGY SOLUTIO 27,875 1,562,000 0.40%
70 ORBOTECH LTD 45,221 1,511,000 0.38%
71 FACEBOOK INC 13,062 1,503,000 0.38%
72 PALATIN TECHNOLOGIES INC COM 2,906,037 1,481,000 0.37%
73 Catabasis Pharmaceuticals Inc 387,943 1,400,000 0.35%
74 ASTRAZENECA PLC 50,000 1,366,000 0.35%
75 Marinus Pharmaceuticals Inc 1,340,588 1,354,000 0.34%
76 BOEING CO 8,392 1,306,000 0.33%
77 REPROS THERAPEUTICS INC 978,800 1,292,000 0.33%
78 SUMMIT THERAPEUTICS PLC 147,450 1,262,000 0.32%
79 Axovant Sciences LTD 100,000 1,242,000 0.31%
80 Syndax Pharmaceuticals Inc 166,310 1,192,000 0.30%
81 Pieris Pharmaceuticals 810,000 1,134,000 0.29%
82 MASTERCARD INCORPORATED 10,825 1,118,000 0.28%
83 MYOKARDIA INC 83,240 1,078,000 0.27%
84 ProQR Therapeutics NV 200,000 980,000 0.25%
85 VTV THERAPEUTICS INC 200,000 966,000 0.24%
86 RA PHARMACEUTICALS INC COM 60,000 911,000 0.23%
87 THERMO FISHER SCIENTIFIC INC 6,363 898,000 0.23%
88 LA JOLLA PHARMACEUTICAL CO 50,677 888,000 0.22%
89 PALO ALTO NETWORKS INC 7,052 882,000 0.22%
90 PROSHARES TR 18,650 761,000 0.19%
91 IMMUNE DESIGN CORP 103,000 567,000 0.14%
92 ONCOBIOLOGICS INC 174,477 525,000 0.13%
93 Sunesis Pharmaceuticals, Inc. 125,000 453,000 0.11%
94 MIRATI THERAPEUTICS INC COM 80,528 383,000 0.10%
95 SOLAREDGE TECHNOLOGIES INC 26,203 325,000 0.08%
96 CABLE ONE INC 500 311,000 0.08%
97 SITEONE LANDSCAPE SUPPLY INC 8,820 306,000 0.08%
98 HORIZON PHARMA PLC 18,100 293,000 0.07% Call
99 UNITEDHEALTH GROUP INC 1,700 272,000 0.07%
100 MOHAWK INDS 1,100 220,000 0.06%
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Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001178913-17-000411, filed 2017.02.13).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.