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Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q4)
Portfolio Summary: 104 holdings with a total value of $395,050,000.
#
Name
Shares
Value ($)
%
Options
Notes
51 ARDELYX INC COM 151,813 2,156,000 0.55%
52 KITE PHARMA INCORPORATED 50,000 2,242,000 0.57%
53 PORTOLA PHARMACEUTICALS INC 100,000 2,244,000 0.57%
54 Aevi Genomic Medicine Inc 450,000 2,331,000 0.59%
55 INOTEK PHARMACEUTICALS CORP 401,764 2,451,000 0.62%
56 XENON PHARMACEUTICALS INC 328,029 2,526,000 0.64%
57 STARBUCKS CORP 45,631 2,533,000 0.64%
58 ACCELERON PHARMA INC 100,000 2,552,000 0.65%
59 Nice Systems LTD Sponsored 38,323 2,635,000 0.67%
60 CLEARSIDE BIOMEDICAL INC 300,000 2,682,000 0.68%
61 ISHARES RUSSELL 2000 GROWTH 12,000 2,682,000 0.68% Put
62 TESARO INCORPORATED 20,000 2,690,000 0.68%
63 ADVANCE AUTO PARTS INC 16,059 2,716,000 0.69%
64 RETROPHIN INC 143,974 2,725,000 0.69%
65 DBV TECHNOLOGIES S A 79,058 2,777,000 0.70%
66 GENOCEA BIOSCIENCES INC 696,273 2,869,000 0.73%
67 SCHLUMBERGER LTD 34,361 2,885,000 0.73%
68 AIR PRODS & CHEMS INC 21,165 3,044,000 0.77%
69 FIDELITY NATL INFORMATION SV 43,503 3,291,000 0.83%
70 VERTEX PHARMACEUTICALS INC 45,000 3,315,000 0.84%
71 FIBROGEN INC 155,700 3,332,000 0.84%
72 AMICUS THERAPEUTICS INC COM 730,000 3,628,000 0.92%
73 VERSARTIS INC 250,000 3,725,000 0.94%
74 BIOMARIN PHARMACEUTICAL INC 45,000 3,728,000 0.94%
75 UNION PAC CORP 36,076 3,740,000 0.95%
76 FOAMIX PHARMACEUTICALS LTD 342,000 3,796,000 0.96%
77 IMMUNOMEDICS INCORPORATED 1,050,000 3,854,000 0.98%
78 NEURODERM LTD 175,951 3,906,000 0.99%
79 VISA INC 51,951 4,053,000 1.03%
80 TEVA PHARMACEUTICAL FIN LLC SR EXC DB0.25 26 6,585 4,247,000 1.08%
81 EIGER BIOPHARMACEUTICALS INC 385,301 4,489,000 1.14%
82 GLYCOMIMETICS INC 745,796 4,549,000 1.15%
83 ALPHABET INC 5,748 4,555,000 1.15%
84 ADAMAS PHARMACEUTICALS INC 270,000 4,563,000 1.16%
85 CORVUS PHARMACEUTICALS INC COM 320,229 4,579,000 1.16%
86 SAGE THERAPEUTICS INC 90,000 4,595,000 1.16%
87 SELECTA BIOSCIENCES INC 268,534 4,605,000 1.17%
88 CHARTER COMMUNICATIONS INC N 16,165 4,654,000 1.18%
89 HORIZON PHARMA PLC 300,000 4,854,000 1.23%
90 SHIRE PLC 32,500 5,537,000 1.40%
91 Ascendis Pharma 326,622 6,611,000 1.67%
92 ACHAOGEN INC COM 514,342 6,697,000 1.70%
93 TEVA PHARMACEUTICAL INDS LTD 215,000 7,794,000 1.97% Call
94 ARRAY BIOPHARMA INC 900,000 7,911,000 2.00%
95 ITURAN LOCATION AND CONTROL 306,633 8,126,000 2.06%
96 SAREPTA THERAPEUTICS INC 398,047 10,918,000 2.76%
97 COLUCID PHARMACEUTICALS ORD 358,000 13,031,000 3.30%
98 ISHARES TR 100,000 13,485,000 3.41% Put
99 ISHARES TR 100,000 13,485,000 3.41% Call
100 ALEXION PHARMACEUTIC 113,000 13,826,000 3.50%
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Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001178913-17-000411, filed 2017.02.13).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.