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Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2015Q2)
Portfolio Summary: 131 holdings with a total value of $1,020,903,000.
#
Name
Shares
Value ($)
%
Options
Notes
51 ORBOTECH LTD 214,922 4,470,000 0.44%
52 ALNYLAM PHARMACEUTICALS INC 37,000 4,435,000 0.43%
53 RELYPSA INC 132,000 4,368,000 0.43%
54 KEMPHARM INC 237,500 4,363,000 0.43%
55 INTERCEPT PHARMACEUTICALS INCORPORATED 17,500 4,224,000 0.41%
56 GENOCEA BIOSCIENCES INC 302,200 4,149,000 0.41%
57 INTRA-CELLULAR THERAPIES INC 128,000 4,090,000 0.40%
58 Biotie Therapies Corp. 196,800 3,930,000 0.38%
59 SPDR INDEX SHS FDS 104,920 3,927,000 0.38%
60 PORTOLA PHARMACEUTICALS INC 86,000 3,917,000 0.38%
61 MEDIVATION INC 34,115 3,896,000 0.38%
62 FOAMIX PHARMACEUTICALS LTD 380,000 3,895,000 0.38%
63 DEPOMED INC 180,000 3,863,000 0.38%
64 Nivalis Therapeutics Inc 255,000 3,863,000 0.38%
65 Receptos Inc 20,000 3,801,000 0.37%
66 Sunesis Pharmaceuticals I 1,235,000 3,717,000 0.36%
67 Life Technologies Corp 209,027 3,696,000 0.36%
68 A O SMITH 50,620 3,644,000 0.36%
69 SPDR SER TR 80,080 3,536,000 0.35%
70 DYNAVAX TECHNOLOGIES CORP 150,000 3,514,000 0.34%
71 SAGE THERAPEUTICS INC 48,000 3,504,000 0.34%
72 KITE PHARMA INCORPORATED 56,970 3,473,000 0.34%
73 Marinus Pharmaceuticals Inc 298,533 3,463,000 0.34%
74 Arrowhead Pharma Inc 475,000 3,396,000 0.33%
75 HALOZYME THERAPEUTICS INC 150,000 3,387,000 0.33%
76 OCULAR THERAPEUTIX INC 160,000 3,365,000 0.33%
77 Pieris Pharmaceuticals 1,200,000 3,300,000 0.32%
78 RAPTOR PHARMACEUTICAL CORP 206,500 3,261,000 0.32%
79 THERAPEUTICSMD INC 412,500 3,242,000 0.32%
80 MACROGENICS INC 85,000 3,227,000 0.32%
81 TRILLIUM THERAPEUTICS INC 147,000 3,208,000 0.31%
82 PTC THERAPEUTICS INC 66,500 3,201,000 0.31%
83 ACCELERON PHARMA INC 100,000 3,164,000 0.31%
84 VERIFONE SYS INC 93,055 3,160,000 0.31%
85 UNIQURE NV 115,000 3,105,000 0.30%
86 FIVE PRIME THERAPEUTICS INC 125,000 3,105,000 0.30%
87 APPLIED GENETIC TECHNOL CORP 200,124 3,070,000 0.30%
88 MELLANOX TECHNOLOGIES LTD 62,850 3,054,000 0.30%
89 Tekmira Pharmaceuticals Corp. 255,000 3,024,000 0.30%
90 MIRATI THERAPEUTICS INC COM 95,000 2,990,000 0.29%
91 APPLE INC 23,223 2,913,000 0.29%
92 IMMUNE DESIGN CORP 140,000 2,891,000 0.28%
93 PTC THERAPEUTICS INC 600 2,888,000 0.28% Call
94 STARBUCKS CORP 53,583 2,873,000 0.28%
95 MEDICINES CO 1,000 2,861,000 0.28% Call
96 Carbylan Therapeutics Inc. 400,000 2,860,000 0.28%
97 WIX COM LTD 120,305 2,842,000 0.28%
98 CYTOKINETICS INC 422,250 2,838,000 0.28%
99 COLUCID PHARMACEUTICALS ORD 317,250 2,824,000 0.28%
100 IONIS PHARMACEUTICAL 48,000 2,762,000 0.27%
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Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001178913-15-002526, filed 2015.08.06).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.