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Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2015Q4)
Portfolio Summary: 118 holdings with a total value of $682,991,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 A O SMITH 2,700 207,000 0.03%
2 ISRAEL CHEMICALS LTD SHS 69,083 280,000 0.04%
3 GENVEC INC 186,500 343,000 0.05%
4 Life Technologies Corp 36,450 358,000 0.05%
5 BIOMARIN PHARMACEUTICAL INC 3,700 388,000 0.06%
6 EZCHIP SEMICONDUCTOR F 20,447 505,000 0.07%
7 Catabasis Pharmaceuticals Inc 80,742 640,000 0.09%
8 Former Charter Communication (Del 5/18/2016) 4,026 737,000 0.11%
9 WIX COM LTD 35,460 807,000 0.12%
10 ELLOMAY CAPITAL LIMITED 95,653 824,000 0.12%
11 DELPHI AUTOMOTIVE PLC 10,065 863,000 0.13%
12 ARRAY BIOPHARMA INC 215,000 907,000 0.13%
13 WABTEC CORP 12,761 908,000 0.13%
14 MANNKIND CORP 760,000 1,102,000 0.16% Call
15 LOXO ONCOLOGY INC COM 45,000 1,280,000 0.19%
16 ProQR Therapeutics NV 150,000 1,302,000 0.19%
17 Carbylan Therapeutics Inc. 360,000 1,303,000 0.19%
18 Strongbridge Biopharma plc 181,818 1,382,000 0.20%
19 NXP SEMICONDUCTORS N V 16,920 1,426,000 0.21%
20 AXALTA COATING SYS LTD 56,173 1,497,000 0.22%
21 ADR - Nabriva Therapeutics AG- Usd 157,500 1,504,000 0.22%
22 NOVARTIS A G 18,000 1,549,000 0.23%
23 TESARO INCORPORATED 30,686 1,605,000 0.23%
24 Aldeyra Therapeutics Inc 238,500 1,617,000 0.24%
25 GW PHARMACEUTICALS PLC 23,790 1,652,000 0.24%
26 TRILLIUM THERAPEUTICS INC 132,300 1,668,000 0.24%
27 OCERA THERAPEUTICS INC 550,000 1,716,000 0.25%
28 Nivalis Therapeutics Inc 231,548 1,792,000 0.26%
29 Pieris Pharmaceuticals 810,000 1,855,000 0.27%
30 TOBIRA THERAPEUTICS INC 187,622 1,886,000 0.28%
31 SCYNEXIS INC 304,600 1,892,000 0.28%
32 EDGE THERAPEUTICS INC 155,000 1,938,000 0.28%
33 AXSOME THERAPEUTICS INC COM 220,000 2,009,000 0.29%
34 ABEONA THERAPEUTICS INC 600,000 2,016,000 0.30%
35 ARBUTUS BIOPHARMA CORP 454,500 2,023,000 0.30%
36 CYNAPSUS THERAPEUTICS INC 134,037 2,070,000 0.30%
37 PALATIN TECHNOLOGIES INC COM 3,132,926 2,080,000 0.30%
38 PTC THERAPEUTICS INC 66,020 2,139,000 0.31%
39 VITAE PHARMACEUTICALS INC 120,000 2,172,000 0.32%
40 DYNAVAX TECHNOLOGIES CORP 90,000 2,174,000 0.32%
41 COGNIZANT TECHNOLOGY SOLUTIO 36,600 2,197,000 0.32%
42 MEDICINES CO 60,000 2,240,000 0.33%
43 DIMENSION THERAPEUTICS INC 200,000 2,256,000 0.33%
44 FORWARD PHARMA A/S 121,500 2,309,000 0.34%
45 SUMMIT THERAPEUTICS PLC 202,220 2,321,000 0.34%
46 HALOZYME THERAPEUTICS INC 135,000 2,340,000 0.34%
47 ADVANCE AUTO PARTS INC 15,555 2,341,000 0.34%
48 COLUCID PHARMACEUTICALS ORD 285,525 2,390,000 0.35%
49 EXELIXIS INC 450,000 2,538,000 0.37%
50 UNIQURE NV 153,500 2,539,000 0.37%
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Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001178913-16-004256, filed 2016.02.11).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.