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Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q3)
Portfolio Summary: 107 holdings with a total value of $614,197,000.
#
Name
Shares
Value ($)
%
Options
Notes
51 Call GILD $70.0 Exp Jun 16, 2017 39,200 3,102,000 0.51% Call
52 ACORDA THERAPEUTICS INC 148,000 3,090,000 0.50%
53 ENDO INTL PLC 150,000 3,023,000 0.49%
54 FIBROGEN INC 145,700 3,016,000 0.49%
55 Aldeyra Therapeutics Inc 368,500 2,893,000 0.47%
56 DBV TECHNOLOGIES S A 79,058 2,872,000 0.47%
57 KITE PHARMA INCORPORATED 50,000 2,793,000 0.45%
58 APPLE INC CALL 18,500 2,759,000 0.45% Call
59 SNAP ON INC 18,130 2,755,000 0.45%
60 Audentes Therapeutics, Inc. 150,000 2,672,000 0.44%
61 FORWARD PHARMA A/S 121,500 2,552,000 0.42%
62 ISHARES TR 20,500 2,546,000 0.41% Put
63 Syndax Pharmaceuticals Inc 166,310 2,521,000 0.41%
64 MEDGENICS INC 450,000 2,507,000 0.41%
65 VERSARTIS INC 200,000 2,450,000 0.40%
66 Marinus Pharmaceuticals Inc 1,340,588 2,440,000 0.40%
67 Catabasis Pharmaceuticals Inc 387,943 2,390,000 0.39%
68 DERMIRA INC COM 70,000 2,367,000 0.39%
69 VistaGen Therapeutics Inc 544,100 2,263,000 0.37%
70 STARBUCKS CORP 41,600 2,252,000 0.37%
71 Egalet Corp 292,500 2,226,000 0.36%
72 ADVANCE AUTO PARTS INC 14,569 2,173,000 0.35%
73 ADVAXIS INC COM NEW 200,000 2,138,000 0.35%
74 ARDELYX INC COM 151,813 1,964,000 0.32%
75 TRILLIUM THERAPEUTICS INC 132,300 1,955,000 0.32%
76 XENON PHARMACEUTICALS INC 228,029 1,847,000 0.30%
77 PARATEK PHARMACEUTICALS INC 140,000 1,821,000 0.30%
78 SUMMIT THERAPEUTICS PLC 197,450 1,813,000 0.30%
79 REPROS THERAPEUTICS INC 863,807 1,805,000 0.29%
80 ADURO BIOTECH INC 140,000 1,740,000 0.28%
81 Nivalis Therapeutics Inc 204,700 1,664,000 0.27%
82 KERYX BIOPHARMACEUTICALS INCORPORATED 311,600 1,655,000 0.27%
83 EDGE THERAPEUTICS INC 150,000 1,562,000 0.25%
84 IMMUNE DESIGN CORP 203,000 1,539,000 0.25%
85 BURLINGTON STORES INC 18,500 1,499,000 0.24%
86 Pieris Pharmaceuticals 810,000 1,482,000 0.24%
87 SHIRE PLC 7,500 1,454,000 0.24%
88 VTV THERAPEUTICS INC 200,000 1,438,000 0.23%
89 MYOKARDIA INC 83,240 1,360,000 0.22%
90 AC IMMUNE SA 79,800 1,314,000 0.21%
91 IMMUNOMEDICS INCORPORATED 400,000 1,300,000 0.21%
92 PALATIN TECHNOLOGIES INC COM 1,906,037 1,199,000 0.20%
93 PALO ALTO NETWORKS INC 7,052 1,124,000 0.18%
94 ARBUTUS BIOPHARMA CORP 300,000 1,032,000 0.17%
95 SAPIENS INTL CORP N V SHS NEW 80,844 1,032,000 0.17%
96 MIRATI THERAPEUTICS INC COM 150,000 992,000 0.16%
97 ONCOBIOLOGICS INC 200,000 850,000 0.14%
98 ARROWHEAD PHARMACEUTICALS IN 100,000 735,000 0.12%
99 ORMAT TECHNOLOGIES INC 7,640 370,000 0.06%
100 ALIMERA SCIENCES INC 200,715 299,000 0.05%
Page 2 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001178913-16-006879, filed 2016.11.14).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.