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Institutional Investment Manager
BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP (CIK: 0001263508) incorporated in Delaware, located at 860 Washington Street, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q1)
Portfolio Summary: 134 holdings with a total value of $9,482,104,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 BIOTIME INC 20,084 12,000 0.00%
2 CYCLACEL PHARMACEUTICALS INC 13,253 76,000 0.00%
3 APTOSE BIOSCIENCES INC 33,397 100,000 0.00%
4 CHEMOCENTRYX INC 49,064 122,000 0.00%
5 ACHAOGEN INC COM 100,000 276,000 0.00%
6 LA JOLLA PHARMACEUTICAL CO 13,746 287,000 0.00%
7 Foundation Medicine 20,892 380,000 0.00%
8 DISCOVERY LABORATORIES INC N 254,973 426,000 0.00%
9 RITTER PHARMACEUTICALS INC 400,000 452,000 0.00%
10 CHIMERIX INC 115,216 589,000 0.01%
11 Aldeyra Therapeutics Inc 142,000 595,000 0.01%
12 BIODELIVERY SCIENCES INTL IN 210,021 678,000 0.01%
13 ALNYLAM PHARMACEUTICALS INC 11,340 712,000 0.01%
14 ARBUTUS BIOPHARMA CORP 180,582 746,000 0.01%
15 ACCELERON PHARMA INC 28,765 759,000 0.01%
16 FIVE PRIME THERAPEUTICS INC 19,247 782,000 0.01%
17 ADAPTIMMUNE THERAPEUTICS PLC 100,000 813,000 0.01%
18 TENAX THERAPEUTICS INC 420,000 861,000 0.01%
19 GW PHARMACEUTICALS PLC 15,000 1,082,000 0.01%
20 PALATIN TECHNOLOGIES INC COM 2,050,000 1,107,000 0.01%
21 AMARIN CORP PLC 801,860 1,227,000 0.01%
22 ASSEMBLY BIOSCIENCES INC 250,000 1,255,000 0.01%
23 MAST THERAPEUTICS INC COM 4,797,442 1,309,000 0.01%
24 Sierra Oncology, Inc. 200,000 1,348,000 0.01%
25 CELLECTIS S A 50,000 1,375,000 0.01%
26 DYNAVAX TECHNOLOGIES CORP 75,000 1,443,000 0.02%
27 AFFIMED N V COM 400,000 1,496,000 0.02%
28 OPHTHOTECH CORP 35,649 1,507,000 0.02%
29 STEMLINE THERAPEUTICS INC 333,497 1,554,000 0.02%
30 CYTRX CORP 659,995 1,769,000 0.02%
31 MEDIWOUND ORD 226,000 1,824,000 0.02%
32 IRONWOOD PHARMACEUTICALS INC 169,163 1,851,000 0.02%
33 KARYOPHARM THERAPEUTICS INC COM 216,990 1,936,000 0.02%
34 IMMUNE DESIGN CORP 148,937 1,936,000 0.02%
35 TRILLIUM THERAPEUTICS INC 211,792 1,959,000 0.02%
36 AURINIA PHARMACEUTICALS INC 711,499 2,082,000 0.02%
37 ENANTA PHARMACEUTICALS INC 75,357 2,213,000 0.02%
38 Proteon Therapeutics Inc 298,591 2,311,000 0.02%
39 IONIS PHARMACEUTICALS INC COM 57,140 2,314,000 0.02%
40 PROTALIX BIOTHERAPEUTICS INC 3,423,000 2,334,000 0.02% PRN
41 ARRAY BIOPHARMA INC 3 06/01/2020 3,000,000 2,382,000 0.03% PRN
42 Sunesis Pharmaceuticals I 4,450,000 2,403,000 0.03%
43 ADAMAS PHARMACEUTICALS INC 172,630 2,496,000 0.03%
44 UNIQURE NV 230,000 2,732,000 0.03%
45 INVIVO THERAPEUTICS HLDGS CORPORATION COM NEW 400,000 2,792,000 0.03%
46 EPIZYME INC COM 232,481 2,818,000 0.03%
47 OSIRIS THERAPEUTICS INC NEW COM 499,193 2,850,000 0.03%
48 JUNO THERAPEUTICS INC COM 80,000 3,047,000 0.03%
49 ADR - Nabriva Therapeutics AG- Usd 350,000 3,136,000 0.03%
50 Curis, Inc 1,999,303 3,219,000 0.03%
Page 1 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-16-102596, filed 2016.05.16).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.