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Institutional Investment Manager
BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP (CIK: 0001263508) incorporated in Delaware, located at 860 Washington Street, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q3)
Portfolio Summary: 134 holdings with a total value of $11,019,928,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 BIOTIME INC 20,084 17,000 0.00%
2 CYCLACEL PHARMACEUTICALS INC 13,253 90,000 0.00%
3 CHEMOCENTRYX INC 49,064 296,000 0.00%
4 LA JOLLA PHARMACEUTICAL CO 13,746 327,000 0.00%
5 Sierra Oncology, Inc. 200,000 364,000 0.00%
6 CYTRX CORP 659,995 388,000 0.00%
7 ACHAOGEN INC COM 100,000 479,000 0.00%
8 Foundation Medicine 20,892 488,000 0.00%
9 BIODELIVERY SCIENCES INTL IN 210,021 567,000 0.01%
10 ABEONA THERAPEUTICS INC 101,680 610,000 0.01%
11 ARBUTUS BIOPHARMA CORP 180,582 621,000 0.01%
12 CHIMERIX INC 115,216 638,000 0.01%
13 WINDTREE THERAPEUTICS INC 254,973 653,000 0.01%
14 RITTER PHARMACEUTICALS INC 400,000 672,000 0.01%
15 ADAPTIMMUNE THERAPEUTICS PLC 100,000 705,000 0.01%
16 MADRIGAL PHARMACEUTICALS INC 57,762 732,000 0.01%
17 ALNYLAM PHARMACEUTICALS INC 11,340 769,000 0.01%
18 DYNAVAX TECHNOLOGIES CORP 75,000 787,000 0.01%
19 INFINITY PHARMACEUTICALS INC 580,400 905,000 0.01%
20 APTOSE BIOSCIENCES INC 404,211 909,000 0.01%
21 MAST THERAPEUTICS INC COM 8,584,051 944,000 0.01%
22 TENAX THERAPEUTICS INC 420,000 972,000 0.01%
23 FIVE PRIME THERAPEUTICS INC 19,247 1,010,000 0.01%
24 ACCELERON PHARMA INC 28,765 1,041,000 0.01%
25 Aldeyra Therapeutics Inc 142,000 1,110,000 0.01%
26 AFFIMED N V COM 400,000 1,112,000 0.01%
27 IMMUNE DESIGN CORP 148,937 1,129,000 0.01%
28 FULGENT GENETICS INC 125,000 1,153,000 0.01%
29 COLUCID PHARMACEUTICALS ORD 30,310 1,156,000 0.01%
30 CELLECTIS S A 50,000 1,204,000 0.01%
31 PALATIN TECHNOLOGIES INC COM 2,050,000 1,289,000 0.01%
32 SERES THERAPEUTICS INC 125,000 1,536,000 0.01%
33 MYOKARDIA INC 100,000 1,634,000 0.01%
34 OPHTHOTECH CORP 35,649 1,644,000 0.01%
35 MEDIWOUND ORD 226,000 1,740,000 0.02%
36 UNIQURE NV 230,000 1,760,000 0.02%
37 ASSEMBLY BIOSCIENCES INC 250,000 1,803,000 0.02%
38 SCYNEXIS INC 467,600 1,810,000 0.02%
39 ENANTA PHARMACEUTICALS INC 75,357 2,005,000 0.02%
40 IONIS PHARMACEUTICALS INC COM 57,140 2,094,000 0.02%
41 KARYOPHARM THERAPEUTICS INC COM 216,990 2,111,000 0.02%
42 EPIZYME INC COM 232,481 2,288,000 0.02%
43 PROTALIX BIOTHERAPEUTICS INC 3,423,000 2,294,000 0.02% PRN
44 JUNO THERAPEUTICS INC COM 80,000 2,401,000 0.02%
45 ADR - Nabriva Therapeutics AG- Usd 350,000 2,468,000 0.02%
46 OSIRIS THERAPEUTICS INC NEW COM 499,193 2,476,000 0.02%
47 SELECTA BIOSCIENCES INC 178,950 2,550,000 0.02%
48 AEGLEA BIOTHERAPEUTICS INC 404,230 2,591,000 0.02%
49 ENDOCYTE INC 868,983 2,685,000 0.02%
50 INVIVO THERAPEUTICS HLDGS CORPORATION COM NEW 400,000 2,720,000 0.02%
Page 1 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-16-134352, filed 2016.11.14).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.