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Institutional Investment Manager
BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP (CIK: 0001263508) incorporated in Delaware, located at 860 Washington Street, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2015Q2)
Portfolio Summary: 126 holdings with a total value of $11,400,413,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 BIOTIME INC 20,084 23,000 0.00%
2 CYCLACEL PHARMACEUTICALS INC 13,253 85,000 0.00%
3 APTOSE BIOSCIENCES INC 33,397 170,000 0.00%
4 CHEMOCENTRYX INC 49,064 404,000 0.00%
5 FIVE PRIME THERAPEUTICS INC 19,247 478,000 0.00%
6 ACHAOGEN INC COM 100,000 603,000 0.01%
7 Foundation Medicine 20,892 707,000 0.01%
8 UNIQURE NV 30,000 810,000 0.01%
9 ACCELERON PHARMA INC 28,765 910,000 0.01%
10 OHR PHARMACEUTICAL INC 370,370 930,000 0.01%
11 Aldeyra Therapeutics Inc 142,000 1,102,000 0.01%
12 TENAX THERAPEUTICS INC 355,348 1,311,000 0.01%
13 ALNYLAM PHARMACEUTICALS INC 11,340 1,359,000 0.01%
14 MEDIWOUND ORD 225,000 1,591,000 0.01%
15 BIODELIVERY SCIENCES INTL IN 210,021 1,672,000 0.01%
16 BIOTA PHARMACEUTIALS INC COM 830,440 1,719,000 0.02%
17 DERMIRA INC COM 100,000 1,755,000 0.02%
18 Ascendis Pharma 100,000 1,768,000 0.02%
19 RITTER PHARMACEUTICALS INC 400,000 1,780,000 0.02%
20 LOXO ONCOLOGY INC COM 100,000 1,803,000 0.02%
21 CELLECTIS S A 50,000 1,804,000 0.02%
22 PALATIN TECHNOLOGIES INC COM 2,050,000 1,825,000 0.02%
23 ADAPTIMMUNE THERAPEUTICS PLC 100,000 1,833,000 0.02%
24 OPHTHOTECH CORP 35,649 1,856,000 0.02%
25 IRONWOOD PHARMACEUTICALS INC 169,163 2,040,000 0.02%
26 AURINIA PHARMACEUTICALS INC 711,499 2,130,000 0.02%
27 Tekmira Pharmaceuticals Corp. 180,582 2,142,000 0.02%
28 ZIOPHARM ONCOLOGY INC 189,259 2,271,000 0.02%
29 MAST THERAPEUTICS INC COM 4,707,464 2,307,000 0.02%
30 Marinus Pharmaceuticals Inc 200,000 2,320,000 0.02%
31 DISCOVERY LABORATORIES INC N 3,569,643 2,427,000 0.02%
32 PROTALIX BIOTHERAPEUTICS INC 3,423,000 2,606,000 0.02% PRN
33 VITAE PHARMACEUTICALS INC 187,597 2,701,000 0.02%
34 BELLEROPHON THERAPEUTICS INC 350,000 2,776,000 0.02%
35 IMMUNE DESIGN CORP 148,937 3,076,000 0.03%
36 Proteon Therapeutics Inc 176,762 3,157,000 0.03%
37 IONIS PHARMACEUTICAL 57,140 3,288,000 0.03%
38 INTRA-CELLULAR THERAPIES INC 104,166 3,328,000 0.03%
39 ENANTA PHARMACEUTICALS INC 75,357 3,390,000 0.03%
40 Curis, Inc 1,077,663 3,567,000 0.03%
41 ARRAY BIOPHARMA INC 3 06/01/2020 3,000,000 3,780,000 0.03% PRN
42 NEURODERM LTD 250,000 3,838,000 0.03%
43 STEMLINE THERAPEUTICS INC 333,497 3,925,000 0.03%
44 JUNO THERAPEUTICS INC COM 80,000 4,266,000 0.04%
45 Receptos Inc 23,900 4,542,000 0.04%
46 ASSEMBLY BIOSCIENCES INC 250,000 4,815,000 0.04%
47 CYTRX CORP 1,319,989 4,910,000 0.04%
48 SERES THERAPEUTICS INC 125,000 5,188,000 0.05%
49 VANDA PHARMACEUTICALS INC COM 409,881 5,201,000 0.05%
50 AERIE PHARMACEUTICALS INC COM 299,356 5,284,000 0.05%
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Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-15-049845, filed 2015.08.14).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.