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Institutional Investment Manager
BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP (CIK: 0001263508) incorporated in Delaware, located at 860 Washington Street, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q1)
Portfolio Summary: 134 holdings with a total value of $9,482,104,000.
#
Name
Shares
Value ($)
%
Options
Notes
51 CORSICANTO LTD 15,000,000 12,103,000 0.13% PRN
52 XENCOR INC COM 872,072 11,703,000 0.12%
53 DERMA SCIENCES ORD 3,752,390 11,632,000 0.12%
54 OMEROS CORP 749,250 11,493,000 0.12%
55 EXELIXIS INC 2,580,000 10,320,000 0.11%
56 DIMENSION THERAPEUTICS INC 1,251,881 9,802,000 0.10%
57 GLOBAL BLOOD THERAPEUTICS INCORPORATED 600,000 9,516,000 0.10%
58 Ascendis Pharma 505,521 9,377,000 0.10%
59 ZOGENIX INC 1,000,000 9,240,000 0.10%
60 ALCOBRA LTD 2,336,359 8,855,000 0.09%
61 ALKERMES PLC 250,251 8,556,000 0.09%
62 Life Technologies Corp 2,137,606 8,422,000 0.09%
63 LIGAND PHARMACEUTICALS INC 73,386 7,859,000 0.08%
64 ULTRAGENYX PHARMACEUTICAL INC COM 123,894 7,844,000 0.08%
65 SAGE THERAPEUTICS INC 224,048 7,183,000 0.08%
66 MACROGENICS INC 363,676 6,819,000 0.07%
67 CONCERT PHARMACEUTICALS INCORPORATED 495,908 6,774,000 0.07%
68 ProQR Therapeutics NV 1,349,719 6,587,000 0.07%
69 CATALYST PHARMACEUTICALS INC 5,498,459 6,433,000 0.07%
70 DERMIRA INC COM 275,000 5,687,000 0.06%
71 AKARI THERAPEUTICS PLC 395,882 5,542,000 0.06%
72 LION BIOTECHNOLOGIES INC COM 1,066,285 5,417,000 0.06%
73 ENDOCYTE INC 1,695,865 5,257,000 0.06%
74 ARROWHEAD PHARMACEUTICALS IN 1,009,509 4,866,000 0.05%
75 NEURODERM LTD 305,000 4,307,000 0.05%
76 Natera, Inc. 450,000 4,284,000 0.05%
77 VITAE PHARMACEUTICALS INC 637,597 4,227,000 0.04%
78 IGNYTA INC COM 571,000 3,866,000 0.04%
79 LOXO ONCOLOGY INC COM 137,735 3,766,000 0.04%
80 TREVENA INC 450,000 3,722,000 0.04%
81 AERIE PHARMACEUTICALS INC COM 299,356 3,640,000 0.04%
82 AIMMUNE THERAPEUTICS INC COM 250,000 3,390,000 0.04%
83 MEDGENICS INC 765,000 3,366,000 0.04%
84 SERES THERAPEUTICS INC 125,000 3,320,000 0.04%
85 Curis, Inc 1,999,303 3,219,000 0.03%
86 ADR - Nabriva Therapeutics AG- Usd 350,000 3,136,000 0.03%
87 JUNO THERAPEUTICS INC COM 80,000 3,047,000 0.03%
88 OSIRIS THERAPEUTICS INC NEW COM 499,193 2,850,000 0.03%
89 EPIZYME INC COM 232,481 2,818,000 0.03%
90 INVIVO THERAPEUTICS HLDGS CORPORATION COM NEW 400,000 2,792,000 0.03%
91 UNIQURE NV 230,000 2,732,000 0.03%
92 ADAMAS PHARMACEUTICALS INC 172,630 2,496,000 0.03%
93 Sunesis Pharmaceuticals I 4,450,000 2,403,000 0.03%
94 ARRAY BIOPHARMA INC 3 06/01/2020 3,000,000 2,382,000 0.03% PRN
95 PROTALIX BIOTHERAPEUTICS INC 3,423,000 2,334,000 0.02% PRN
96 IONIS PHARMACEUTICALS INC COM 57,140 2,314,000 0.02%
97 Proteon Therapeutics Inc 298,591 2,311,000 0.02%
98 ENANTA PHARMACEUTICALS INC 75,357 2,213,000 0.02%
99 AURINIA PHARMACEUTICALS INC 711,499 2,082,000 0.02%
100 TRILLIUM THERAPEUTICS INC 211,792 1,959,000 0.02%
Page 2 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-16-102596, filed 2016.05.16).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.