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Institutional Investment Manager
BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP (CIK: 0001263508) incorporated in Delaware, located at 860 Washington Street, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2015Q4)
Portfolio Summary: 133 holdings with a total value of $12,071,272,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 BIOTIME INC 20,084 24,000 0.00%
2 CYCLACEL PHARMACEUTICALS INC 13,253 52,000 0.00%
3 APTOSE BIOSCIENCES INC 33,397 84,000 0.00%
4 LA JOLLA PHARMACEUTICAL CO 13,746 371,000 0.00%
5 CHEMOCENTRYX INC 49,064 397,000 0.00%
6 Foundation Medicine 20,892 440,000 0.00%
7 UNIQURE NV 30,000 496,000 0.00%
8 ACHAOGEN INC COM 100,000 574,000 0.00%
9 RITTER PHARMACEUTICALS INC 400,000 680,000 0.01%
10 DISCOVERY LABORATORIES INC N 3,569,643 764,000 0.01%
11 FIVE PRIME THERAPEUTICS INC 19,247 799,000 0.01%
12 ARBUTUS BIOPHARMA CORP 180,582 804,000 0.01%
13 Aldeyra Therapeutics Inc 142,000 963,000 0.01%
14 BIODELIVERY SCIENCES INTL IN 210,021 1,006,000 0.01%
15 CHIMERIX INC 115,216 1,031,000 0.01%
16 ALNYLAM PHARMACEUTICALS INC 11,340 1,068,000 0.01%
17 ADAPTIMMUNE THERAPEUTICS PLC 100,000 1,206,000 0.01%
18 PALATIN TECHNOLOGIES INC COM 2,050,000 1,361,000 0.01%
19 TENAX THERAPEUTICS INC 420,000 1,378,000 0.01%
20 ACCELERON PHARMA INC 28,765 1,403,000 0.01%
21 Marinus Pharmaceuticals Inc 200,000 1,528,000 0.01%
22 CELLECTIS S A 50,000 1,552,000 0.01%
23 CYTRX CORP 659,995 1,749,000 0.01%
24 AURINIA PHARMACEUTICALS INC 711,499 1,789,000 0.01%
25 DYNAVAX TECHNOLOGIES CORP 75,000 1,812,000 0.02%
26 ASSEMBLY BIOSCIENCES INC 250,000 1,878,000 0.02%
27 MEDIWOUND ORD 225,000 1,922,000 0.02%
28 IRONWOOD PHARMACEUTICALS INC 169,163 1,961,000 0.02%
29 MAST THERAPEUTICS INC COM 4,797,442 2,016,000 0.02%
30 STEMLINE THERAPEUTICS INC 333,497 2,104,000 0.02%
31 OHR PHARMACEUTICAL INC 370,370 2,274,000 0.02%
32 PROTALIX BIOTHERAPEUTICS INC 3,423,000 2,375,000 0.02% PRN
33 ENANTA PHARMACEUTICALS INC 75,357 2,488,000 0.02%
34 TRILLIUM THERAPEUTICS INC 211,792 2,671,000 0.02%
35 Natera, Inc. 250,000 2,700,000 0.02%
36 OPHTHOTECH CORP 35,649 2,800,000 0.02%
37 ARRAY BIOPHARMA INC 3 06/01/2020 3,000,000 2,816,000 0.02% PRN
38 FLEXION THERAPEUTICS INC 146,642 2,826,000 0.02%
39 AFFIMED N V COM 400,000 2,848,000 0.02%
40 KARYOPHARM THERAPEUTICS INC COM 216,990 2,875,000 0.02%
41 IMMUNE DESIGN CORP 148,937 2,991,000 0.02%
42 Sierra Oncology, Inc. 200,000 3,008,000 0.02%
43 ADR - Nabriva Therapeutics AG- Usd 350,000 3,367,000 0.03%
44 VITAE PHARMACEUTICALS INC 187,597 3,396,000 0.03%
45 JUNO THERAPEUTICS INC COM 80,000 3,518,000 0.03%
46 IONIS PHARMACEUTICALS INC COM 57,140 3,539,000 0.03%
47 EPIZYME INC COM 232,481 3,724,000 0.03%
48 LOXO ONCOLOGY INC COM 137,735 3,919,000 0.03%
49 Sunesis Pharmaceuticals I 4,450,000 3,994,000 0.03%
50 AMARIN CORP PLC 2,205,710 4,169,000 0.03%
Page 1 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-16-082790, filed 2016.02.16).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.