Dark
Light
System
Institutional Investment Manager
BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP (CIK: 0001263508) incorporated in Delaware, located at 860 Washington Street, New York, NY. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q4)
Portfolio Summary: 133 holdings with a total value of $10,200,965,000.
#
Name
Shares
Value ($)
%
Options
Notes
51 INTRA-CELLULAR THERAPIES INC 609,166 9,192,000 0.09%
52 ALKERMES PLC 150,251 8,351,000 0.08%
53 ABEONA THERAPEUTICS INC 1,684,364 8,169,000 0.08%
54 ACHILLION PHARMACEUTICALS IN 1,856,637 7,668,000 0.08%
55 LIGAND PHARMACEUTICALS INC 73,386 7,457,000 0.07%
56 MACROGENICS INC 363,676 7,434,000 0.07%
57 CONTRAFECT CORP COM 4,045,876 7,080,000 0.07%
58 IMMUNOGEN INC 3,015,353 6,151,000 0.06%
59 DIMENSION THERAPEUTICS INC 1,251,881 5,446,000 0.05%
60 AGIOS PHARMACEUTICALS INC 128,666 5,369,000 0.05%
61 CATALYST PHARMACEUTICALS INC 5,102,153 5,357,000 0.05%
62 INSMED INC 400,000 5,292,000 0.05%
63 INOTEK PHARMACEUTICALS CORP 5,000,000 5,167,000 0.05% PRN
64 ALCOBRA LTD 2,336,359 4,906,000 0.05%
65 RIGEL PHARMACEUTICAL INC 2,018,882 4,805,000 0.05%
66 BIOGEN INC 16,500 4,679,000 0.05%
67 Aevi Genomic Medicine Inc 880,539 4,561,000 0.04%
68 ALDER BIOPHARMACEUTICALS INC 217,328 4,520,000 0.04%
69 LOXO ONCOLOGY INC COM 137,735 4,423,000 0.04%
70 ARRAY BIOPHARMA INC 3 06/01/2020 3,000,000 4,195,000 0.04% PRN
71 STEMLINE THERAPEUTICS INC 333,497 3,568,000 0.03%
72 ULTRAGENYX PHARMACEUTICAL INC COM 50,000 3,516,000 0.03%
73 AKARI THERAPEUTICS PLC 496,901 3,498,000 0.03%
74 MINERVA NEUROSCIENCES INC COM 258,805 3,041,000 0.03%
75 ASSEMBLY BIOSCIENCES INC 250,000 3,038,000 0.03%
76 IGNYTA INC COM 571,000 3,026,000 0.03%
77 SELECTA BIOSCIENCES INC 175,712 3,013,000 0.03%
78 Natera, Inc. 249,269 2,919,000 0.03%
79 ADAMAS PHARMACEUTICALS INC 172,630 2,917,000 0.03%
80 EPIZYME INC COM 232,481 2,813,000 0.03%
81 IONIS PHARMACEUTICALS INC COM 57,140 2,733,000 0.03%
82 RA PHARMACEUTICALS INC COM 177,952 2,703,000 0.03%
83 Sunesis Pharmaceuticals, Inc. 741,665 2,685,000 0.03%
84 TREVENA INC 450,000 2,646,000 0.03%
85 ENANTA PHARMACEUTICALS INC 75,357 2,524,000 0.02%
86 SYROS PHARMACEUTICALS INC 204,465 2,486,000 0.02%
87 OSIRIS THERAPEUTICS INC NEW COM 499,193 2,451,000 0.02%
88 TRILLIUM THERAPEUTICS INC 413,697 2,337,000 0.02%
89 GLYCOMIMETICS INC 381,235 2,326,000 0.02%
90 PROTALIX BIOTHERAPEUTICS INC 3,423,000 2,293,000 0.02% PRN
91 CORBUS PHARMACEUTICALS HLDGS 260,129 2,198,000 0.02%
92 ADR - Nabriva Therapeutics AG- Usd 350,000 2,086,000 0.02%
93 KARYOPHARM THERAPEUTICS INC COM 216,990 2,040,000 0.02%
94 AEGLEA BIOTHERAPEUTICS INC 404,230 1,758,000 0.02%
95 Spring Bank Pharmaceuticals In 219,298 1,752,000 0.02%
96 INVIVO THERAPEUTICS HLDGS CORPORATION COM NEW 400,000 1,680,000 0.02%
97 CONCERT PHARMACEUTICALS INCORPORATED 152,964 1,574,000 0.02%
98 JUNO THERAPEUTICS INC COM 80,000 1,508,000 0.01%
99 SCYNEXIS INC 467,600 1,492,000 0.01%
100 FULGENT GENETICS INC 125,000 1,446,000 0.01%
Page 2 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-17-008836, filed 2017.02.14).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.